"They have a new drug, well according to the FDA it is even though it has no bilogical activity, that encapsulates the chemo drug and delivers its payload to the cancer cells. The drug is called DAVANAT after the inventors and they got this drug after their 4th try at making it back in 2001. DAVANAT is a carbosome and encapsulates the 5-fu. Go to the website and check out the video. Anyhow, the DAVANAT has an affinity for the Galectin-3 lectins which are overly expressed on 75% of all solid tumors. Well guess what, in phase I humans they had a 70% response rate. Are you surprized - probably not. Well now you will be - this was done on stage III/IV patients after 30 days. That is how quick this works. Now let me throw you the kicker. In order to get into this trial you had to be refractory to 5-FU and failed every other therapy. Now sit down - There are ZERO side effects.
They are in Phase II for colon cancer - they met their primary endpoint and stopped enrollment after 15 patients. They have 2 Objective responses and more coming. Think about the number and compare them to AVASTIN. On stage III patients AVASTIN has only a 1% ORR! vs 14% and climbing every month as more responses keep coming. Everyone is stabilized.
What does this mean for cholangio patients. Well DAVANAT works on a wide range of cancers including Cholangio. There are 2 compassionate use patients with cholanio and I believe both are alive. One person was as Oshner and they lost track of her after the hurricanes hit. I believe she is 100% better but no one knows for sure.
Here is my e-mail if you want to contact me to discuss this more --- Message edited by CancerCompass staff: for personal protection, email address removed. Please review CancerCompass Member Guidelines at http://www.cancercompass.com/common/guidelines.html ---- This board doesn't get too much posting.
In my opinion this is the best hope right now for all Cholangio patients. Cancer is all about the receptors not cocktails of chemo.]]>
They are looking for an abcess, no word yet on weather or not they found one.
Its coincedental though his procedure was two and a half weeks ago and this fever was so sudden. similar to your hubbies situation.
Keep you posted.
Thank you so much for sharing your story.
My family just feels so hopeless right now because he has been suffering so much. It almost seems never ending.
I shared your husbands story with my mom and dad and Im hoping they will see that others have been down this road, suffered hell and come back around.
Dad was rush to the hospital last night his fever was 104.2 and he was in great pain.
His fever is down this morning and like you previously warned they think he may have an abcess.
They are scheduling an ultrasound and maybe cTscan for this afternoon.
He is feeling much better compared to when he was admitted.
Will keep you posted
How is your husband doing??
Thank you all for the emails, I am so sorry it has taken me so long to post.
Its been a journey and a half since the last time I wrote.
Dad is not doing so good right now and it is taking a toll on everyone.
Its very difficult to see someone suffer so much, or see someone who was once so strong and full of life weaken and appear to except defeat! ((WE LOVE YOU DAD IF YOU READ THIS STAY STRONG, YOU KNOW WE ALL LOVE YOU))
It is also hard to watch those around him suffer due to watching him suffer
(I LOVE YOU MOM, VENT TO ME ANY TIME) I KNOW you will read this!!!
Here is an update...
Last time I posted we had just left the ONC who told us they were cancelling Chemo because he could not see the tumour and that he obviously couldn't treat something he couldn't see. He sent us to another surgeon for a second (technically 5th) opinion!
This sugeon was very upset at the fact that the last hospital felt that my dad was unresectable and that he would certainly die within a year.
Thats the good news ...HOWEVER
We also found out that the first hospital didn't tell us that my dads bile ducts were blocked for such a long period of time (YOU KNOW WHILE HE WAS TRYING TO CONVINCE HIS STUPID GP THAT THERE REALLY WAS SOMETHING WRONG AND THAT IT WAS NOT JUST REFLUX, STRESS OR GALL STONES) anyways the blockage caused 3/4 of his liver to die!
The new surgeon and team, feel my Dad is a candidate for resection. Well at least so far. He will be reassessed next month.
He has had a drain put in and has been suffering because of it.
His spirits are down his hope seems to be slipping.
We are starting him back on the Pau D'arco tonight as he was off of it before and during this procedure. We are hoping to see an improvement and hopefully it will help alleviate some of the pain he has been experiences.
Then we are hoping to help him put on weight, he has lost so much weight and has no appitite.
I HATE CANCER
I hope to read some positive posts tonight.
I hope to hear of some success stories
and I hope and prey we all get throught this horrible horrible disease!