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		<title><![CDATA[discussion boards — changing chemos]]></title>
		<link>http://www.cholangiocarcinoma.org/punbb/viewtopic.php?id=8619</link>
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		<description><![CDATA[The most recent posts in changing chemos.]]></description>
		<lastBuildDate>Tue, 24 Jul 2012 22:50:59 +0000</lastBuildDate>
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			<title><![CDATA[Re: changing chemos]]></title>
			<link>http://www.cholangiocarcinoma.org/punbb/viewtopic.php?pid=63559#p63559</link>
			<description><![CDATA[<p>Lainey and Percy,<br />&nbsp; &nbsp;Thanks so much for your quick replies.&nbsp; This has been such a bone of contention between us.&nbsp; I was starting to believe that he (Dr. R. Smith, SC Oncology) wasn&#039;t being aggressive enough (too afraid of side effects) and Chris wasn&#039;t anxious to go down the Gem/Cis route either.&nbsp; I was starting to get frustrated with the whole thing and worried we weren&#039;t doing the right thing.&nbsp; You really set my mind at ease.&nbsp; Thanks.<br />&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Dianne</p>]]></description>
			<author><![CDATA[null@example.com (dmj4ctj)]]></author>
			<pubDate>Tue, 24 Jul 2012 22:50:59 +0000</pubDate>
			<guid>http://www.cholangiocarcinoma.org/punbb/viewtopic.php?pid=63559#p63559</guid>
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			<title><![CDATA[Re: changing chemos]]></title>
			<link>http://www.cholangiocarcinoma.org/punbb/viewtopic.php?pid=63540#p63540</link>
			<description><![CDATA[<p>Hi,<br />Actually I think your oncologist did his/her homework for your husband&#039; CCA.<br />The Gem/Cis is not an universal treatment of choice for ICCA but it is easier to prescribe since that is appear to be the easiest and&nbsp; most prescribed regimen in CCA.</p><p>But other regimens work as well as Gem/cis and cause much less side effects.<br />1.Xeloda( 5FU in oral form) provides patient compliance by the oral route;<br />2,Oxaliplatin is much less toxic than cisplatin;unlike cisplatin, oxaliplatin is not associated with significant renal(kidney) or auditory toxicity(tinnitus)&nbsp; and hematological toxicity (blood cells) is usually mild .<br /> 3.Both platium agents will cause nausea and vomiting but usually it will be taking care by the pre-chemotherapy antinausea medications, such as Aloxi,Zofran and Decadron .<br />4. Both platium agents will elevate the hepatic enzymes and bilirubin and the same apply to both capecitabine and gemcitabine.</p><p>If the the tumor is &quot;stable&quot;,and nothing else changes significantly, I guess your oncologist wants a consistent (5FU) level from you by asking you to take the Xyloda twice daily after meals.And he/she wants to start use one of the agent from the platium family-oxaliplatin to see whether the result will be better than gemcitabine.<br />It is a cautious decision and I like your oncologist. In short, every body can recommend the use&nbsp; of GEM/Cis first,but I think your oncologist does more than just that. May I ask what is his/her name and where he/she works?<br />This is just my opinion, the rest is up to you. remember I am just a patient as your husband havine the same ICCA&nbsp; and I am not a doctor.<br />God bless.</p>]]></description>
			<author><![CDATA[null@example.com (PCL1029)]]></author>
			<pubDate>Tue, 24 Jul 2012 16:26:00 +0000</pubDate>
			<guid>http://www.cholangiocarcinoma.org/punbb/viewtopic.php?pid=63540#p63540</guid>
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			<title><![CDATA[Re: changing chemos]]></title>
			<link>http://www.cholangiocarcinoma.org/punbb/viewtopic.php?pid=63536#p63536</link>
			<description><![CDATA[<p>dmj4ctj, Please keep in mind that everything seems to work differently for different people and situations however, GEM/CIS seems to be the &#039;cocktail&#039; of choice. Sending you much good luck and hugs!</p>]]></description>
			<author><![CDATA[null@example.com (Lainy)]]></author>
			<pubDate>Tue, 24 Jul 2012 13:29:34 +0000</pubDate>
			<guid>http://www.cholangiocarcinoma.org/punbb/viewtopic.php?pid=63536#p63536</guid>
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			<title><![CDATA[changing chemos]]></title>
			<link>http://www.cholangiocarcinoma.org/punbb/viewtopic.php?pid=63534#p63534</link>
			<description><![CDATA[<p>Husband needs to change regimens quickly.&nbsp; Liver enzymes and bilirubin going up.&nbsp; doctor wants to switch to xeloda/oxiliplatin combo from gemzar/xeloda.&nbsp; Wondering if Gemzar/cisplatitin is better way to go. What are your thoughts?</p>]]></description>
			<author><![CDATA[null@example.com (dmj4ctj)]]></author>
			<pubDate>Tue, 24 Jul 2012 09:34:32 +0000</pubDate>
			<guid>http://www.cholangiocarcinoma.org/punbb/viewtopic.php?pid=63534#p63534</guid>
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