grsharp....most importantly, have you received an explanation to your wife's significant nausea, vomiting and abdominal pain? When did it start? What are her latest scans showing? This is important to ask, because sometimes there are ways to bypass certain areas blocked by the tumor, if indeed that is the reason for her problems at this time.
I think liquid biopsies have not yet fully been explored, but it provides an alternative for some tumor tissue sampling. The idea behind is that tumors shed into the blood stream.
"The patterns of genomic changes identified by a liquid biopsy test in a large collection of patient blood samples largely matched patterns of genetic changes seen in large tumor biopsy profiling studies.
Tumor biopsies are an essential part of cancer care. They can confirm a cancer diagnosis, identify the cell type of the tumor, and, increasingly, they are used to determine whether a patient’s tumor contains particular genetic alterations that may make them candidates for targeted therapies.
However, tumor biopsies require invasive procedures, including surgery, and some patients may not be candidates because of poor health or because of a tumor’s location in the body. In addition, after the initial testing and analyses of biopsy samples, not enough additional tissue may be left for comprehensive molecular profiling, or it may not be of sufficient quality for profiling.
In the matched blood ctDNA/tumor biopsy samples, the liquid biopsy also identified genetic alterations not present in tumor biopsy samples that are known to make tumors resistant to therapy. These included mutations in the EGFR, ALK, and KRAS genes that are known to cause resistance to currently available targeted agents.
Overall, the test identified these resistance mutations in 27% of patients, Dr. Mack said during an interview. In most cases, he continued, the mutations were likely not present at the time of the initial tumor biopsy, instead emerging as a patient’s disease progressed on therapy"
Read more: https://www.cancer.gov/news-events/canc … uid-biopsy
Sending tons of good wishes and crossing my fingers for a targeted drug to be identified with the blood test.