1

(0 replies, posted in Announcements)

Team Lindsey - Tough Mudder

Drew will be running the "tough mudder race in memory of his sister Lindsey.

"This Septmeber 21st I will be participating in an event called the Tough Mudder. For those of you who are unaware of the event, it is a 10-12 mile foot race, riddled with obstacles and mud. It is going to be a test of will and endurance, one that I am hoping i pass. After all, if Lindsey had to go through 2 and a half years of fight and pain and sickness to make it home, i better be able to put up with it for a few hours. On that day, I am going to approach the starting line with shoes untied. When the journey starts, I am going to tie my shoes, just like Lindsey, to make it home."

https://www.crowdrise.com/TeamLindsey/f … rewfortney

https://www.crowdrise.com/fundraise-and … rewfortney

Good luck Drew and thank you so much for this!

ERCP-directed radiofrequency ablation and photodynamic therapy are associated with comparable survival in the treatment of unresectable cholangiocarcinoma.

"Survival after ERCP-directed RFA and PDT was not statistically different in patients with unresectable CCA. A randomized, controlled trial is warranted to validate these preliminary results."

http://www.ncbi.nlm.nih.gov/pubmed/24836747

Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target.

" Taken together, our findings indicated that upregulated neddylation pathway was involved in ICC progression and interference in this pathway could be a promising target for ICC therapy."

http://www.ncbi.nlm.nih.gov/pubmed/25229838

In vitro and In vivo Antitumor Activity of Tiliacorinine in Human Cholangiocarcinoma.

"These results demonstrated antitumor effects of tiliacorinine on human CCA in vitro and in vivo. Tiliacorinine may be an effective agent for CCA treatment."

http://www.ncbi.nlm.nih.gov/pubmed/25227861

And thanks for that as well!

Excellent news Marion, thanks so much for posting that here!

7

(30 replies, posted in Clinical Trials)

Thanks for that Marion.

Jean-Marie,

Sorry to hear the news from Jeff's scan results. I know  that it is not the news that you wanted to hear but please do not give up hope here. My fingers are crossed that Jeff can get on to the immunotherapy trial. Please know that we are all here for you and hoping for some good news for you and Jeff.

My best to you both,

Gavin

Impact of Microenvironment and Stem-Like Plasticity in Cholangiocarcinoma: Molecular Networks and Biological Concepts.

"This review will emphasize the dynamic interplay between stem-like intrinsic and TME-extrinsic pathways, which may represent novel options for multi-targeted therapies in CCA."

http://www.ncbi.nlm.nih.gov/pubmed/25220250

10

(2 replies, posted in In Remembrance)

Dear Carl,

I'm so very sorry to hear of the passing of your Lynn. Please accept my sincere condolences. I know that words will not help ease your pain right now  but please know that my thoughts are with you and your family at this time, I so wish that I could help right now. You know Carl that we are all here for you and send our love to you,

Hugs,

Gavin

Thanks for posting this Marion. Lets hope that it does indeed shorten the time for enrollment in trials.

Thanks for this Julie! I know that it will be of great help to many, many people.

Thanks for that Marion very useful.

14

(12 replies, posted in Members' Cafe)

Great news Julie about the port, superb!!!!

And a pot of chilli, YUM!!!! smile

15

(163 replies, posted in General Discussion)

Hi Tom,

Sorry to hear this latest news about Ben. Grrrrrr to fluid on the lungs! Hoping that Ben's med team can get to the root cause of this issue and do something about the cause of it and not just drain it away. Good idea contacting MD Anderson for their thoughts on this and please let us know how you get on with that.

Glad that you were at least able to enjoy some of your trip and my fingers are crossed for Ben.

My best to you both,

Gavin

Induction of cancer-related microRNA expression profiling using excretory-secretory products of Clonorchis sinensis.

"These findings constitute further our understanding of the multiple cholangiocarcinogenic pathways triggered by liver fluke infection."

http://www.ncbi.nlm.nih.gov/pubmed/25217977

Impact of Microenvironment and Stem-Like Plasticity in Cholangiocarcinoma: Molecular Networks and Biological Concepts.

"This review will emphasize the dynamic interplay between stem-like intrinsic and TME-extrinsic pathways, which may represent novel options for multi-targeted therapies in CCA."

http://www.journal-of-hepatology.eu/art … 7/abstract

18

(4 replies, posted in General Discussion)

Hi Maria,

Welcome to the site. Sorry that you had to find us all here and I'm sorry to hear about your mum. But I am glad that you've joined in with us all as you're in the best place for support and help and you will get loads of each from everyone here.

I'm with Lainy on never having heard of a hospital refusing t help someone for their bili levels being too high. That seems very strange to me to say the least. I hope that others from your area will be along soon with some other suggestion to treatment facilities that are close to your mum. I can't really help with that as I am from Scotland.

I do hope that the radiation treatment that your mum is away to start works well for her and does indeed lead to her being able to start the chemo afterwards. My fingers are crossed for your mum with her treatment and please let us know how things go. If you have any questions please feel free to ask and we'll do our best to help if we can. Please know as well that we are here for you and we care.

My best to you and your mum,

Gavin

Liver transplantation for intrahepatic cholangiocarcinoma.

http://www.ncbi.nlm.nih.gov/pubmed/25214036

Change in total lesion glycolysis and clinical outcome after 90Y radioembolization in intrahepatic cholangiocarcinoma.

http://www.ncbi.nlm.nih.gov/pubmed/25213104

Capsaicin suppresses the migration of cholangiocarcinoma cells by down-regulating matrix metalloproteinase-9 expression via the AMPK–NF-κB signaling pathway.

http://link.springer.com/article/10.100 … 014-9678-x

Val,

I so agree with Lainy that taking everything one day at a time is the right thing to do. I did that too when I lost my dad and I know that things are tough for you right now. Please know as well that we are all here for you too.

Hugs,

Gavin

Nonoknife Technology from a pancreatic cancer site in the UK -

http://www.pancreaticcancer.org.uk/abou … technology

Princess Grace Hosp in the UK -

http://www.theprincessgracehospital.com … nanoknife/

Trial in Italy for Nanoknife -

Pilot Study of Irreversible Electroporation (IRE) to Treat Metastatic Liver Cancer & Cholangiocarcinoma

http://www.cancer.gov/clinicaltrials/se … id=9419395

Gavin

GROWTH REGULATION OF THE INTRAHEPATIC BILIARY TREE.

http://projectreporter.nih.gov/project_ … amp;icde=0

Radioactive Stents for Treatment of Unresectable Biliary Tract Cancer.

http://clinicaltrials.gov/ct2/show/NCT02238613