I'm just starting - had my first round on Friday - began with an anti-nausea drug, then Decadron (a steroid) to boost the anti-nausea drug. Then oxilaplatin and leucovorin together followed by a 46-hour infusion of 5-FU.
I'd forgotten that the anti-nausea drug and the steroid wore off in about 48 hours and was wondering why I felt crummy - fatigue and nausea, and nothing tastes good. That said, I'm still only 4-days from the beginning of the treatment and don't know how long I will feel like this.
I found walking helps relieves the nausea at least for a while.