OK, this is just my opinion only, but I say go for the trial! One of my biggest gripes is that we have to fail a chemo regimen before we can enter a trial. I feel that if we are wanting to try a trial that we would be stronger going into it if we had not already beaten down our bodies with a chemo regimen.
Now, an exception for me would be to do a chemo regimen in order to shrink tumor to have it surgically removed. If that is a possibility and there are no mets, then I would do it in hopes to gain surgery.
I was diagnosed at age 41, that was 6 years ago. I had liver resection with recurrence 3 months later to my lungs. I was then labeled stage IV terminal. I wanted to immediately start a trial, but couldn't for insurance reasons at that time. I then did Gem/Cis for 6 months with horrible side effects, did Gem alone with growth of tumors, did Taxotere with horrible side effects. Four years ago, I entered into a clinical trial at NIH. I have had great success, but wish I could have skipped the first 2 years of chemo.
This is my opinion only, but I believe the treatments to come are going to be the game changers in this disease, and we wont't have them until trials are available and patients are participating. I feel strongly about new options for all of us, and have high HOPE for what is to come.
Best wishes for your decisions, and know that whatever route you two go, we are all here to support and cheer you on! Prayers and hugs to you!