I am a week away from the end of an OX-40 Phase I drug trial.
When I found out I had bile duct cancer (stage IV, unresectable) I just happened to be at a hospital whose research lab developed an OX-40 treatment, and was conducting a trial I qualified for. The trial is open to people with all sorts for tumors. It is the only treatment offering the possibility of long term immunity that I am aware of, in the US, for cholangiocarcinoma. It is my understanding that the other immune system drugs being tried in the US are more like drug therapy than inoculation. In the OX-40 trial you get 3 infusions in the first week, then tests & observation for the next 2 months. I had no prior treatment for cancer.
The tests they did after 1 month did not tell us much. Happily, all of my blood test results started out in the normal range, and have stayed there. The only thing they can get an image of is something in my liver that may be a cyst. That showed no change. If it is a cyst and not a malignancy, I may not know if the treatment had any effect at the end of the trial. I'll post again when I get the results.
The two big questions are, of course: Did this treatment reduce the amount of cancer in my body? and Will my immune system continue to destroy this nasty critter whenever it is encountered?
Here are some websites that have more info on OX-40 and the drug trial. The location is Providence Cancer Center in Portland Oregon.
News Release on drug trial: http://www.providence.org/oregon/about_ … ial306.htm
Info on the development of the therapy: http://www.providence.org/Oregon/Progra … andrew.htm
This page has links to Dr. Weinberg's publications.
contact for drug trials: Katie Strauss, RN 503-215-2619
http://www.providence.org/Oregon/Progra … trials.htm
Medline has a ton of articles on OX-40 as a component of the immune system.
Wikipedia has a good article.