Introduction -is this cc?
My mother, 65 yrs old was diagnosed with metastatic adenocarcinoma of the liver last June. She had been complaining of apathy for food particularly intolerance to the smell of cooking, itching and bloated feeling in the stomach for 2-3 months and an ultrasound showed the metastatic deposits in the liver.Colonoscopy and endoscopy did not reveal anything. PET/CT results
Right lobe lesion 15 by 8.3 cm
Left lobe lesion 5.7 by 4.8 cm
- multiple, necrotic fdg avid lesions in both lobes of the liver suggest metastatic
-FDG avid pre vascular nodes suggest metastatic disease
-no other FDG avid lesion is seen elsewhere to suggest a possible primary neoplasm
CEA 19.1 CA19.9 -427 AFP 1.73 CA 125 - 256
Our oncologist started her on gemcytabine and xeloda 3 cycles of 21 days. She tolerated the chemo very well. A review was done in Aug 2011
Shrinkage right lobe 9.7 by 5.2 cm left lobe 1.9 by 2.4 cm
CEA 12.2 ( earlier 19.1)
CA 19.9 88.9 ( earlier 427)
CA 125 56.6 ( earlier 256)
The same chemo gemcytabine 1600 mg and xeloda 4 tabs daily was continued for 3 more cycles of 21 days and review PET CT done in End of Oct 2011-
Right lobe lesion stayed the same at 9.7 by 5.2 cm
Left lobe lesion reduced to 1.7 by. 1 cm( last scan 1.9 by 2.4 cm)
CA 19.9 - 125( earlier 89.9)
CEA 14.2( earlier 12.1)
CA 125 70.8. ( earlier 96.8)
She was given about 45 days of rest from chemo . Her appetite improved and she felt her symptoms had disappeared.
In December 2011 she was started on gemcytabine and oxitan for 4 cycles each of 15 days. But from15 Dec onwards she felt the same symptoms . so a mid term review was done in Feb 2012. CT scan results
Right lobe lesion increased to 11.1 by 7.8( earlier 9.7 by 5.2 cm)
Left lobe 1.7 by 1 cm same as before
CEA 53.8( earlier 14.2 cm)
CA 19.9 990 ( earlier 125)
CA 125 -305( earlier 70.8)
No new sites
Doctor feels it could be cc and not pancreatic but says treatment options are the same he advises.
Now she has been started on 48hour IV of 5fu, 750 mg -9 hrs each
Irrinotican 240 mg -2hrs
Calciumleucorin 300mg -2hours
1st cycle completed had a neutrophil boosting injection felt very weak had mouth sores, throat infection.
Was treated on antibiotics and improved
2nd cycle over. Much better tolerance.
She has no diabetes, hypertension but has been asthmatic for years but no other known illness.
has been tolerating chemo well except the 1st dose of 5 fu which gave her a fever and she felt weak for 2days.
Sorry for all these details. But just wanted to find out if anyone had a similar experience - metastaitic adenocarcinoma of liver with unknown primary and can suggest what options are available for her.