Topic: AZD6244

Who else amongst us is trying this innovative oral chemo AZD6244?  Dan is in his first week and suffering explosive diarrhea, nausea and dry mouth. There was one episode of emesis. Anti-nausea meds eliminated that symptom. Lethargy and sleepiness are apparent as well. Appetite seems fine...weight is steady thus far. I am interested in others experience with this trial drug. Thanks- Sandy

Re: AZD6244

Hi, I am brand new to this site. I will be starting AZD6244 next Friday. I will be able to offer my experiences after that.  I am very curious to know how Dan continues to do on this medication.  Where are you being treated?  Thanks- Jenn

Re: AZD6244

Hi Dmann2 and Jenn,  I have researched this treatment through Massey's cancer Center.  From what I understand ,it is a phase II trial being conducted under the NCI protocol 7909 and Primary Investigator: Lee,Ruey Min.   Are we talking about the same location or are you guys trying this some where else?  If it has NCI protocol,  I imagine it can be tried at several locations.  Members would love to know location, as It shows trial is still open. We certainly would like to hear your experiences as well. Wish you both only the best with your outcomes of treatments.
God Bless,
Jeff G.

Take it to the Limit,One More Time! (Eagles)

Re: AZD6244

Hi,
   I am beginning the trial at Ohio State. Based on the information that they provided me they are looking for 35 patients to take part. I believe that I may be number 19, they said they are also administiring the medication out of Baylor. My oncologist and adminstrator of the trial is Dr. Tanios Bekaii-Saab.  I will updated once I start the trial, which hopefully is Friday, if all the stars finally align, and the Cleveland Clinic sends my tissue samples.

Jenn

Re: AZD6244

Jenn, certainly wish you the best and will look forward to your updates of this trial, as will other members of cholangiocarcinoma Organization.

Power and God's Strenght,
Jeff G.

Take it to the Limit,One More Time! (Eagles)

Re: AZD6244

Greetings, guys! Clinical trial for Dan is at OSU, with Dr. Saab as well. Blood tests are done bi- weekly; and the first cat scan since Dan's start of AZD6244 is scheduled in 3 weeks. The diarrhea has lessened with regular use of immodium, and anti nausea meds let him keep the AZD6244 down. His biggest complaint is cotton mouth. Hard candies and sips of liquids are helpful.  Dan's appetite is good. All seems well. We must "Hurry Up and Wait!" just like all of you. God grant us patience and bless us all. Sandy

7 (edited by JeffG Sun, 07 Sep 2008 19:37:06)

Re: AZD6244

Jenn and Dan,   Thank You so much for keeping us up to date.  A lot of members will be keeping a eye on this trial.  We are really routing for you guys.  Does it require a hospital stay. Or do you know the protocol yet? Sorry, I'm a little excited when new trials pop up.

God's Strenght,
Jeff G.

Take it to the Limit,One More Time! (Eagles)

8 (edited by marions Sun, 07 Sep 2008 23:01:42)

Re: AZD6244

Jenn....These are some of the recommendations for dry mouth.  Sip of water every few minutes, try very sweet or tart foods and beverages (such as lemonade: these foods may help your mouth make more salivia.  (Do not try this if you have a tender mouth or sore throat and the sweet or tart foods make it worse.) Suck on hard candy or popsicles or chew gum.  Eat soft and pureed foods, which may be easier to swallow. Keep lips moist with lip salves. Moisten food with sauces, gravies, and salad dressing to make it easier to swallow.  If dry mouth is severe, ask your doctor about products that coat, protect, and moisten your mouth and throat.  These are sometimes called "artificial salivia". 
Copied from: U.S. Department of Health and Human Services, NIH, NCI "Eating hints for cancer patients, before, during & after treatment.
Sending tons of good wishes your way.
Marion

THIS INFORMATION IS NOT INTENDED NOR IMPLIED TO BE A SUBSTITUTE FOR PROFESSIONAL MEDICAL ADVICE. YOU SHOULD ALWAYS SEEK THE ADVICE OF YOUR PHYSICIAN OR OTHER QUALIFIED HEALTH CARE PROVIDER

Re: AZD6244

So far so good!
    I just started yesterday. 

The last week was exhausting, many bumps in the road to try to start this drug, waiting for tissue samples, insurance denial, and anxiety forcing me to repeat my EKG 7 times before I was eligable.  But we are very excited about the results they have been having. I will keep you updated through the upcoming weeks.

This link has more information regarding the trial. It does not require a hospital stay,and the drug is fully administered at home. Follow up visits and labs every 2 weeks, and scans every 8 weeks.

http://clinicaltrials.gov/ct2/show/NCT0 … mp;rank=18

And thank you for the post regarding dry mouth.  I went last night and stocked up on hard candies, gum, along with immodium, and compazine.

Thanks Jenn

Re: AZD6244

Hi Jenn.... Thanks for the link to the study.  So interesting and more genetically involved fom reading it.  I noticed the time start and end dates have already passed.  Are they still conducting the study and have they made any comments on previous patients outcomes.  I know i 'm just full of questions.  I guess I could just call them.  Wish you the best Jenn. I see you had to have quite a few test and patholgy samples taken.  Do you remember anything in particular that they might have said would ne a disqualifier? Sorry, enough questions.  Press on my brave warrior!
God Bless You,
Jeff G.

Take it to the Limit,One More Time! (Eagles)

Re: AZD6244

Jeff,

    They did start the trial last fall, and they are still accepting patients, I believe I am #19 of the 35 they are looking for. The doctors and the nurses at the clinic say they are having very hopeful results. They have people that have been on the medication since December, and are still responding to the medication. The end date is 2009, for reporting purposes.

     They originally thought that this drug would aggravate heart problems, although they have found that to be false. The current study requires patients to have a 'good' EKG ( my medical knowledge drops off here, something about the Qtc intervals). The doctors have petitioned, and are awaiting the NCI to remove this requirement. (So it was hard to swallow that I almost was left off this study because of the EKG) But luckily I passed it. So the evaluation was as such: Physical....(vital signs), Blood work, EKG, Chest X-ray, CT scans -  Tumor Measurement,and a Biopsy (they had plenty from my liver resection in May).

I would think that some of the lab work may be a catch to exclude some people, and maybe the amount of treatment  that one has previously underwent:
Criteria:

Received ≤ 1 prior systemic anticancer therapy, including chemoembolization
Received prior cryotherapy, radiofrequency ablation, ethanol injection, transarterial chemoembolization, or photodynamic therapy AND meets the following criteria:

More than 6 weeks have elapsed since any of the prior therapy described above
Indicator lesion(s) must be outside the area of prior treatment OR must demonstrate clear evidence of disease progression if the only indicator lesion is inside the prior treatment area
Indicator lesion must have clearly distinct edges on CT scan
Prior radiotherapy with or without the use of a fluoropyrimidine as a radiosensitizer is allowed, provided more than 12 weeks have elapsed since treatment

But I don't truly understand all of the above. I am sure they can answer any questions that you may have.  I am sort of new to this battle. I have had 4 doses, and so far no side effects. I am happy to just have started something.

Jenn

12 (edited by JeffG Wed, 10 Sep 2008 11:23:51)

Re: AZD6244

Hi Jenn,  Thanks for the information.  I probally would not qualify due to all the chemotherapy I've had ,plus my heart beat average about 32-34bpm and skips a little.  Doesn't seem to bother me any. Probally potassium flexing.  Thanks again, and glad your off and running with this trial. Toes ,fingers, and eyes crossed for positive results.  Well, I'll send a few prayers your way instead of keeping the eyes crossed ,that make me a bit dizzy. Ha!  Bless You Girl!
jeff G.

Take it to the Limit,One More Time! (Eagles)

13 (edited by SHodge Sat, 29 Nov 2008 21:35:59)

Re: AZD6244

My aunt Amy was recently diagnosed with CC a few months ago. Last month she had a consult with Dr. Saab at OSU to start the clinical study of AZD6244. After being told that she qualified for the study her insurance company(Anthem) told her that they would not pay. We are now in the appeal process and hoping for postive news.
My question to anyone that has been on the study is what type of sucess have you had on AZD6244? Have the side effects been managable?
Amy is losing hope everyday . She feels the insurance company would rather not help her at all. I am trying to give her postive news while we wait?

Re: AZD6244

shodge...welcome to our site.  I am sending all my best wishes to your Aunt Amy.  As far as I can recall we have have three separate postings on this clinical trial study of AZD6244.  Until others have a chance to respond to you it might help you to use the "Search Function" to find these threads.  Simply, enter "AZD6244" and these discussions will come up for you.  Please, encourage you Aunt to stay hopeful since many times we have read about the insurance companies reversing their decisions in re: to their payment of different treatment options.  I am hoping for her to be one of those people.  Has Dr. Saab been able to talk to the insurance company on your Aunt's behalf?
Sending tons of good wishes your way

THIS INFORMATION IS NOT INTENDED NOR IMPLIED TO BE A SUBSTITUTE FOR PROFESSIONAL MEDICAL ADVICE. YOU SHOULD ALWAYS SEEK THE ADVICE OF YOUR PHYSICIAN OR OTHER QUALIFIED HEALTH CARE PROVIDER

Re: AZD6244

Hi All,   

    It has been a long time since I have posted or even looked at this site.  My cancer was not stopped by this drug,AZD6244.  They discontinued me the end of the year.   I had been in a fog.  I have lost about 50 pounds since summer, and had grown pretty weak.  The James decided that my best route at this time is to follow the normal protocol of gemzar and cistplatin.  I began the chemo the beginning of January, but have since had many other problems.  I developed blood clots in my lungs, and my ulcerative colitis became out of control, my sodium,and hemoglobin, and potassium were all out of wack.

I have to many issues that the doctors at the James didn't do a very good job of managing everything, and it resulted in two different hospitalizations in January.  I have switched doctors, and will begin chemo again tomorrow.  I am very nervous that I will return to the fog that I have been in for a few months, but am enjoying feeling well right now.  We have to live in the day, and enjoy the small things.   They should put all cancer patients on prednisone, or another drug to help appetite. 

Jenn
37 - mom of 2, diagnosed May 2008.

Re: AZD6244

Jenn,

As the Aussies say, good on ya, that's the fighting spirit! I know this cancer is like a streamroller but I really think that the right doctor can make all the difference, I hope it does for you.

Patty

Re: AZD6244

Jenn....I am hoping for a better experience with the more established drugs of Gemzar/Cisplatin.  You might already know this but, I thought to mention it anyway:  The National Cancer Institute booklet: Eating Hints for Cancer Patients: Before, During & After Tratments provides more tips about how to make eating easier and more enjoyable.  It also gives many ideas about how to eat well and get extra protein and calories during cancer treatment.  For a free copy of this booklet, ask you nurse or call the Cancer Information Services at 1.800.422.6237.  Of course, there is plenty of advise others can give you when it comes to fighting of the weightloss generally associated with the chemotherapy treatments.  Good luck, tomorrow. 
Sending all my best wishes your way,
Marion

THIS INFORMATION IS NOT INTENDED NOR IMPLIED TO BE A SUBSTITUTE FOR PROFESSIONAL MEDICAL ADVICE. YOU SHOULD ALWAYS SEEK THE ADVICE OF YOUR PHYSICIAN OR OTHER QUALIFIED HEALTH CARE PROVIDER

Re: AZD6244

Hi Jenn, have you tried Megace or Marinol as an appetite stimulant?  You might want to ask your doctor about it.  Good to hear from you.  Take care and hang in there.

Carol

Re: AZD6244

My mom is on Megace and it has worked like a miracle drug in her case.  She eats everything and has kept her weight up like it should be.

Pam

My Mom lost her one year battle with CC on April 3, 2009.

"A prognosis is simply an audit of how truly precious each day is.  Live each day to the maximum, celebrate what was, and what is - Don't spend your life looking forward to what will or might be." .... words of wisdom from my beloved son on hearing of his grandmother's CC prognosis.