Topic: Can Oxaliplatin replace Cisplatin?

Hello, I live in Taiwan. My Mom was diagnosed with cholangiocarcinoma, Stage IV at July 31. Doctor said resection has not been suitable for Mom, so he suggested us to receive chemotherapy. Mom had 5-FU plus leucovorin for four times, and last Thursday, doctor told us Mom's CA19-9 was keep going up, from 159 to 230 during the four weeks. Doctor said it means 5-FU doesn't work for Mom, so he said we need to change drugs.

I saw many posts on this board, and it seems some people has good response to Gemzar / Cisplatin. I searched on the website, it seems that Oxaliplatin is similar to Cisplatin, but less side effect. Anyone can give me suggestion? I have to discussed Mom's drug with the doctor this Thursday.

I'm very glad that I found this site. Because there are so few people has experience on cc, I can't find a Chinese discussion board. Thanks all of you provide so much useful information , cherish experience and kindly supports. And sorry, due to my English is not quite good, I can't describe my thought very correctly. I hope someday, I can share my Mom's successful experience and give others support on this board.

Re: Can Oxaliplatin replace Cisplatin?

Hi, Viola,

Welcome to our site. No apologies needed, the content is more important than how you say it, though humor always seems to help. I had the Gemzar/Cisplatin combination and it worked for me. The medications to minimize nausea were necessary, but usually worked. The combination does have a tendency to cause women to enter menopause if they have not already completed that, though. I did not have anything to help combat the hot flashes and chills that were probably due to the menopause more than anything else. So my side effects for the first series (8 cycles) were much more obvious than the second time around, about a year later. The oxiplatin and cisplatin both have a platinum component, so they are similar. I am not sure of the differences, though, and have not had the oxiplatin at all. Currently, I am in remission and hoping to stay that way. Please keep us posted on your Mom, and visit as often as you need to, whether to ask questions, share frustrations or successes, or just to visit.
Louise

Re: Can Oxaliplatin replace Cisplatin?

Welcome Viola to our world that is full of caring and loving people from all over the world. You did amazingly well on your post, understood it all! So sorry you have to travel this road but you will find a ton of support here. I just wanted to welcome you and so sorry you had to come.  Please keep us posted as we all care.

Teddy ~In our hearts forever~ATTITUDE is EVERYTHING
Any suggestion I offer is intended as friendly advice based solely on my own experience. Please consult your doctor for professional guidance.

Re: Can Oxaliplatin replace Cisplatin?

Viola....the incidence of CC in Taiwan is one of the highest in the world.  There is quite a bit of research going on, in your country.  I will try to find a researcher for you but, don't know how successful I can be at that. In the mean time, please, contact the major research hospitals in your area (or, beyond) and ask for the names of oncologists treating this cancer. And, please, stay in touch.
Best of wishes coming you way,
Marion

THIS INFORMATION IS NOT INTENDED NOR IMPLIED TO BE A SUBSTITUTE FOR PROFESSIONAL MEDICAL ADVICE. YOU SHOULD ALWAYS SEEK THE ADVICE OF YOUR PHYSICIAN OR OTHER QUALIFIED HEALTH CARE PROVIDER

Re: Can Oxaliplatin replace Cisplatin?

Louise, thanks a lot for your exeperience sharing. I saw many people has good reposonse to Gemzar/Cisplatin chemotherapy, I am hoping that my Mom's cc will be controlled by it too. But my Mom seems to be afraid of the side effect, she still want to keep 5-FU regime that don't make her too uncomfortable. Sometimes I feel very struggling, I don't know if I should push my Mom to accept what I want her to do, such as eat lots of vegetables, trying Chinese medicine..etc. Afterall, I don't know if they are effective to control tumor growth.

Now, I also don't know if Gemzar/Cisplatin has real benefit for Mom. But I agree with what Doctor suggested: CA19-9 keep going up probably means 5-FU has no effect on controling Mom's cc. Mom want to do CT to further confirm the effect of 5-FU. But that might take 2 weeks, I am worried that she'll waste time. It's so difficult to make a decision...... I should make a decision for her? Or I should let her make choice by herself?

Lainy and Marions, thank you for your kindly support. In fact, I come to this website everyday from I found this site. My English reading skill is okay, but writing is not good enough  tongue , so I didn't post a lot. But it's certain that I will keep visit here often.

Re: Can Oxaliplatin replace Cisplatin?

Viola...you have great skills. Please, continue to write to us.  I don't believe for two weeks will make much of a difference.  It appears that your Mom wants to be sure of her decision regarding the treatment.  You are in a great position of researching and finding out much information for your Mom.  When you are speaking with the physicians,  you will be able to ask informed questions and your Mom can benefit from hearing the answers.  Your Mom probably would like to have some control over this disease and deciding on a specific treatment may just give her that. 
You are a great daughter,
Many good wishes coming your way,
Mar

THIS INFORMATION IS NOT INTENDED NOR IMPLIED TO BE A SUBSTITUTE FOR PROFESSIONAL MEDICAL ADVICE. YOU SHOULD ALWAYS SEEK THE ADVICE OF YOUR PHYSICIAN OR OTHER QUALIFIED HEALTH CARE PROVIDER

Re: Can Oxaliplatin replace Cisplatin?

Hi Viola,

If your mother will also accept Chinese medicine, I would like to suggest that she try qigong. I have been practicing two forms of qigong for about nine months and it has helped me a lot. My tumors are stable and have not gotten any bigger in that time, with no medical treatment. Qigong is very gentle and the exercises can also be done sitting or lying down. I've read that in China, there are special forms of qigong just for people with cancer. Maybe there are teachers who do that in Taiwan too.

All my best wishes to you and your mother--

Kristin

Peace, hope, and healing to all!

Re: Can Oxaliplatin replace Cisplatin?

Kristin, thanks for your suggestion. My mother do some simple Qigong after discharging from hospital. But I read some books about using Qigong to cure cancer, it needs one to two hours per day. My mother only do 20-30 mins around per day.

We go to hospital this morning, the doctor said it's unnecesarry to do CT scan now. I mentioned the ASCO report, and he accept. But my mother still feel afraid of changing 5-FU to other drungs, she's worried about that she'll become very weak and uncomfotable. So the doctor decide to keep 5-FU regime for two times. After two weeks later, if blood test show that CA19-9 keep going up, we should change to Gemzar/Cisplatin.

The doctor said Oxaliplatin is equal to Cisplatin. But I am still not quite sure. Because I found some doctors said Oxaliplatin seems to be weaker in some studies, but that's for breast cancer.

Hopefully, my mother's CA19-9 will be decreased after two weeks...

Re: Can Oxaliplatin replace Cisplatin?

Viola....Several physicians I have been in contact with continue to use Oxaliplatin.
Marion

THIS INFORMATION IS NOT INTENDED NOR IMPLIED TO BE A SUBSTITUTE FOR PROFESSIONAL MEDICAL ADVICE. YOU SHOULD ALWAYS SEEK THE ADVICE OF YOUR PHYSICIAN OR OTHER QUALIFIED HEALTH CARE PROVIDER