Topic: Oxaliplatin Desensitization Protocol
Hi everyone - just thought I would pass on the details of the desensitization procedure I started and has so far been successful. I've been on FOLFOX6 since September 2009, then in Jan 2010 had an allergic reaction. Had the first desensitization on Feb 4 which went fine, no reaction. Had my second one yesterday, again no reaction. So this is how I'll be receiving this chemo from now on. It takes about 8 hours from start to finish, so in case you have to go through this be prepared for a really long day. I have my bloodwork done the day before to save some time.
Instead of receiving the full dose of oxaliplatin in 1 bag, it is split into 5 smaller doses that are given over a 6 hour period. Before I am given the oxaliplatin, I am given premeds of singulair (pill), pepcid (iv), benedryl (iv), zofran/decodron (iv), and ativan (iv).
Bag 1 of oxaliplatin is given at .01 mg of full dose over 1 hour
Bag 2 is given at 0.1 mg of full dose over 1 hour
Bag 3 is given at 1 mg of full dose over 1 hour
Bag 4 is given at 10 mg of full dose over 1 hour
*I am given another dose of benedryl before bag 5 is given
Bag 5 of oxaliplatin is given at 90 mg over 2 hours
After the last bag is given, the 5FU pump is attached as normal
I no longer get the Leucovorin or the 5FU bolus (due to low platelets)
I sleep until lunch (which my fantastic husband brings me (love Cracker Barrel), then sleep for a while longer, then I'm just kind of groggy the rest of the day. The benedryl/ativan combo wipes me out.
Hope this is helpful.