there are retrospective series and small phrase Ii studies suggest superior outcomes for patients who receive EBRT radiation with or without concomitant chemotherapy or the combination of post-op 5FU plus brachytherapy after resection of cholangiocarcinoma.
for patient who are left with microscopically positive margins after resection,the main benefit of postoperative radiation therapy is a reduction in the rate of local recurrence.
in one study, margin positive resection patients increase their 5 year survival
rate if they received postoperative adjuvant EBRT (34 vs 14%).
In another study,46 cholangiocarcinoma patients(total pop.=128 patients of hepatibiliary ca) had 3D-CRT radiation plus FUDR intrahepetic artery infusion;60% of all patient were free of hepatic progreesion at 3 years.
In short ,receive postoperative adjuvant radiation treatment with or without chemo may prolong survival.
I know the above response may not answer the actual question that you had.
Should i wait until the CCA recur or do the preventive adjuvant radiation treatment as soon as possible?
MY answer is at least ,up to now, there are NO CURE for this disease;all the treatment plans are use to prolong or for palliative purposes;Recurrence is high in this disease(>65%). whether you monitor the disease progress every 3 months with scans like me or wait until the recurrence hit home. it is always a very difficult decision to make. Because there are no guaranteed for either way. But if you,like me, try the best we can, there will be no regrets when the time comes.
Please know that my personal opinion is not intended nor implied to be a substitute for professional medical advice. If provided, information are for educational purposes.Consult doctor is a MUST for changing of treatment plans.