Topic: modified t-cells

This article is not about cholangiocarcinoma.  It's about treating chronic leukemia using the patient's own modified t-cells.  There is hope that if this proves successful it can be used on other types of cancer.   You can goggle Carl June if you are interested - he is very interesting and of course, a genius.


http://www.cbsnews.com/8301-504763_162- … 91704.html

Betsy

2 (edited by eli Tue, 29 Nov 2011 11:46:17)

Re: modified t-cells

Modified T-cells were used in one Japanese trial to treat intrahepatic cholangiocarcinoma.

Clinical utilization of postoperative dendritic cell vaccine plus activated T-cell transfer in patients with intrahepatic cholangiocarcinoma
http://www.ncbi.nlm.nih.gov/pubmed/21874278

ADDED:

An earlier case report by the same group of Japanese doctors.

Intrahepatic cholangiocarcinoma with lymph node metastasis successfully treated by immunotherapy with CD3-activated T cells and dendritic cells after surgery: report of a case.
http://www.ncbi.nlm.nih.gov/pubmed/16715430

Re: modified t-cells

Hi all,

I just came across these articles on immunotherapy. I was wondering whether anyone has access to the full journal articles as i'm only able to access the abstracts?

Has anyone tried immunotherapy instead of chemo, post-surgery?

Thanks a lot,
Jules

Re: modified t-cells

I'm wondering the same thing. My Moms bladder cancer was treated by immunotherapy alone (no chemo or surgery) but it wasn't at an advanced stage. They used a modified tuberculosis bacterium in solution, flooded her bladder for a couple hours at a time and this stimulated an immune response against the "invading pathogens". She's been in remission going on 2 years so were thrilled and intrigued with this line of medicine.
Willow

Willow

Re: modified t-cells

Willow thanks for that and how wonderful that your Mom is doing so great.

Teddy ~In our hearts forever~ATTITUDE is EVERYTHING
Any suggestion I offer is intended as friendly advice based solely on my own experience. Please consult your doctor for professional guidance.

Re: modified t-cells

Hi Willow,

Yes, thanks for the info. We are looking into immunotherapy for my mum as she would ideally like to avoid chemo if possible. Probably a bit crazy I know but that's her choice so we're having to run with it at the moment. We were looking into a vaccine of microbacterium vaccae, which was actually initially used to treat tuberculosis. There's no evidence of it helping in cholangiocarcinoma, that i'm aware of, but we have a friend who was successfully treated with lung cancer on this vaccine and I believe that there is evidence for it helping in other cancers too.

If anyone finds anything interesting on immunotherapy I'd be most grateful to hear about it.

Re: modified t-cells

If anyone is interested, I now have access to the articles above but they're in PDF format. Not sure how to post them on here, but I'm happy to do so if someone tells me how smile

Re: modified t-cells

I would like to see PDF but I don't know how to post it either. Can you email it to us?
Lisa

This Information Is Not Intended Nor Implied To Be A Substitute For Professional Medical Advice. You Should Always Seek The Advice Of Your Physician Or Other Qualified Health Care Provider

Re: modified t-cells

Hi Lisa,

I've just emailed the papers to you. Let me know if you don't receive them.

Jules