Topic: Screening tests available but not conclusive
Presently, I am not aware of any testing sensitive or specific enough for early detection of CC however, there are certain things to consider:
As you may know, CC is associated with inflammatory bowel diseases, history of parasitic disease involving the bilary system, and rarely with Lynch syndrome (a genetic colonic polyposis syndrome). Patients with a background of any of these factors are at somewhat higher risk and perhaps may be warranting more than basic blood chemistries as a method of screening. Of course, those with symptoms (pain, jaundice, etc) warrant more investigation as well.
As for basic screening, fractionated (total and direct) bilirubin, alkaline phosphatase, GGTP, AST, ALT are sufficient.
For those at higher risk, tumor makers such as CEA and CA 19-9 could be included. An ultrasound of the abdomen would be helpful in this group and possibly ultimately a triphasic CT of the abdomen