• pak001
  • Senior Member
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  • From: Cleveland, OH
  • Registered: Fri, 04 Nov 2011
  • Posts: 77

Topic: Heat shock protein 90

Anyone have any experience or knowledge of this target therapy: HSP90-
heat shock protein 90?  It popped up on my FB page and there's not too much info that I can find on it's significance on cholangiocarcinoma

Anna
  • Lainy
  • Lainy
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  • From: Phoenix AZ
  • Registered: Fri, 13 Jan 2006
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Re: Heat shock protein 90

Anna, Gavin just posted a link on this very question today.

Teddy ~In our hearts forever~ATTITUDE is EVERYTHING
Any suggestion I offer is intended as friendly advice based solely on my own experience. Please consult your doctor for professional guidance.
  • Gavin
  • Gavin
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  • From: Scotland - Dundee
  • Registered: Tue, 23 Sep 2008
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Re: Heat shock protein 90

Hi Anna,

Is this what popped up on your FB page today?

http://www.biomedsearch.com/nih/heat-sh … 55701.html

Have you tried using the search forum function at the top of the page to see what else is here on the site?

Best wishes to you,

Gavin

  • eli
  • eli
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  • From: Ottawa, Ontario, Canada
  • Registered: Tue, 08 Nov 2011
  • Posts: 563

Re: Heat shock protein 90

The study that Gavin linked was done in a dish.

17-AAG is the name of the drug.  Heat shock protein 90 (HSP90) is the target of the drug.

17-AAG is also known as Tanespimycin. It was tested in a number of clinical trials:

http://clinicaltrials.gov/ct2/results?term=tanespimycin

None of these trials involved cholangiocarcinoma.

This article says that Bristol-Myers (pharma company) has abandoned development of the drug:

http://www.myelomabeacon.com/news/2010/ … nt-halted/