Topic: Photodynamic Therapy
I was just wondering if anyone has heard of this:
Photodynamic Therapy (PDT)
Photodynamic therapy (PDT) is a new therapy that selectively destroys tumor tissue. A photosensitizer is administered and selectively retained by the target tumor tissue. The photosensitizer is nontoxic in its native state, however, after activation by a light at a particular wavelength, the photosensitizer becomes cytotoxic and produces local tissue destruction. The only relevant side effect seen to date is phototoxicity, which lasts often for 4-6 weeks after drug administration.
Animal and human pilot studies have shown a reduction of up to 60% of tumor volume after administration of PDT with hematoporphyrin. One trial using biliary PDT in patients with unresectable cholangiocarcinoma (Bismuth types III and IV tumors), who failed endoprostheses placement, has resulted in significant improvements in serum bilirubin levels and quality of life scores, with a 30-day mortality of 0% and median survival time of 439 days. Other trials investigating the effect of PDT in patients with unresectable hilar carcinoma who were treated with endoprostheses placement showed a six-month survival rate of 91%. Ninety-six percent of patients improved in terms of cholestasis, performance and quality of life. No adverse side effects were reported.
PDT appears to be a promising therapeutic approach for unresectable cholangiocarcinoma, and combines the two aims of treating cholestasis and reducing tumor growth. The apparent benefit in survival time, however, needs to be confirmed with randomized, controlled trials.
Any views on this??