Re: Cholangiocarcinoma.org Statistics (CONTAINS SURVIVAL STATISTICS)
This post was first postesd on 6/1/13 and edited on 6/4/13 to correct for the inclusion of Klatskin and other tumor data that was contained in the SEER Bile Duct - Intrahepatic file, but was not intrahepatic cholangiocarcinoma. This data has been eliminated in this revised analysis. Also, some surgery cases where the surgery could not be specifically identified as a resection were included in the previous analysis. These were mostly pre-1998 data where surgical codes were not included in SEER. These were also eliminated in this analysis.
This is my first analysis using SEER (Surveillance Epidemiology and End Results) data. I requested a CDROM when I submitted my application to SEER, but just received a username and password to their online data, so I just used that in this analysis.
SEER has several databases and sites containing cholangiocarcinoma data, some of which is duplication, and some of which is not. I used the database "Incidence - SEER 18 Regs Research Data + Hurricane Katrina Impacted Louisiana Cases, Nov 2012 Sub (1973-2010 varying)" and the Site and Morphology "CS Schema v0204" The SEER 18 database has the latest data which goes through 12/31/2010. I found Intrahepatic CC patients in three ofther Site and Morphology sections, but the CS Schema v0204 had the most, a total of 11,789.
The survival curves below show that a single postive node substantially reduces survival for patients who have resected intrahepatic cholangiocarcinoma.
In the analysis, I eliminated those patients with mutiple cancers, patients who had non-resection surgery, and patients who died from causes other than intrahepatic cc or its complications. A total of 355 patients were used in the analysis. These patients were diagnosed with intrahepatic cc from 1998 - 2010, median 2006. Their ages ranged from 17 - 84, median 59 years.
Median survival is 3.42 years for 0 positive LNs and 1.33 years for 1 positive LN. Statistical parameters for the analysis are Chsq = 33.9, 1 degree of freedom, p = 5.78 e-09. I wanted to do this analyis from the start using the posted Cholangiocarcinoma Foundation data, but never could find sufficient data to get a statistically significant comparison. However, I will add those to the plot in a later post to show comparison between those from the boards and SEER's.