Topic: Does Celecoxib/Celebrex Help With Hand-Foot Syndrome?
As a refresher: my husband has extra-hepatic and/or gallbladder CC, Whipple procedure in April, currently on the SWOG S0809 protocol (12 weeks of Gemzar & Xeloda, then 5-6 weeks Xeloda and radiation). He is just now finishing the third cycle of chemo with one more cycle to go.
About three weeks ago my husband developed moderate Hand-Foot Syndrome (HFS) which at this point is mostly confined to his feet. This is a common Xeloda side effect. I've searched the Discussion Board which has been very helpful and so we are doing heavy applications of the lotion with 10% urea as well as the Udderly Smooth cream and topping it off with thick cotton socks. This has kept things tolerable though he did have to stop exercising last week which was disappointing because he felt that helped him mentally and with other symptoms.
I did some PubMed searching and saw that Celecoxib has been used in a few studies and seemed to help with HFS (PubMed results posted below). It also has some anti-tumor activity which was interesting but I'm mostly interested in whether it helps with HFS. I found some posts related to this from much beloved and missed Pharmacist Percy. I think he was experimenting on himself with Celecoxib more for the anti-tumor effect but he did mention that it eased HFS symptoms.
Has anyone else had any experience with Celecoxib/Celebrex as it relates to HFS? We will discuss this with our oncologist but I wanted to reach out to the community as well. Blessings, Tilly
1: Macedo LT, et al.
Prevention strategies for chemotherapy-induced hand-foot syndrome: a systematic review and meta-analysis of prospective randomised trials.
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2: Zhang RX, et al.
Celecoxib can prevent capecitabine-related hand-foot syndrome in stage II and III colorectal cancer patients: result of a single-center, prospective randomized phase III trial.
Ann Oncol. 2012 May;23(5):1348-53. doi: 10.1093/annonc/mdr400. Epub 2011 Sep 22.
3: Zhang RX, et al.
The effect of COX-2 inhibitor on capecitabine-induced hand-foot syndrome in patients with stage II/III colorectal cancer: a phase II randomized prospective study.
J Cancer Res Clin Oncol. 2011 Jun;137(6):953-7. doi: 10.1007/s00432-010-0958-9. Epub 2010 Nov 27.
4: Lin EH, et al. Retrospective study of capecitabine and celecoxib in metastatic colorectal cancer: potential benefits and COX-2 as the common mediator in pain, toxicities and survival?
Am J Clin Oncol. 2006 Jun;29(3):232-9.
5: Lin E, et al.
Effect of celecoxib on capecitabine-induced hand-foot syndrome and antitumor activity. Oncology (Williston Park). 2002 Dec;16(12 Suppl No 14):31-7.
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