They did start the trial last fall, and they are still accepting patients, I believe I am #19 of the 35 they are looking for. The doctors and the nurses at the clinic say they are having very hopeful results. They have people that have been on the medication since December, and are still responding to the medication. The end date is 2009, for reporting purposes.
They originally thought that this drug would aggravate heart problems, although they have found that to be false. The current study requires patients to have a 'good' EKG ( my medical knowledge drops off here, something about the Qtc intervals). The doctors have petitioned, and are awaiting the NCI to remove this requirement. (So it was hard to swallow that I almost was left off this study because of the EKG) But luckily I passed it. So the evaluation was as such: Physical....(vital signs), Blood work, EKG, Chest X-ray, CT scans - Tumor Measurement,and a Biopsy (they had plenty from my liver resection in May).
I would think that some of the lab work may be a catch to exclude some people, and maybe the amount of treatment that one has previously underwent:
Received ≤ 1 prior systemic anticancer therapy, including chemoembolization
Received prior cryotherapy, radiofrequency ablation, ethanol injection, transarterial chemoembolization, or photodynamic therapy AND meets the following criteria:
More than 6 weeks have elapsed since any of the prior therapy described above
Indicator lesion(s) must be outside the area of prior treatment OR must demonstrate clear evidence of disease progression if the only indicator lesion is inside the prior treatment area
Indicator lesion must have clearly distinct edges on CT scan
Prior radiotherapy with or without the use of a fluoropyrimidine as a radiosensitizer is allowed, provided more than 12 weeks have elapsed since treatment
But I don't truly understand all of the above. I am sure they can answer any questions that you may have. I am sort of new to this battle. I have had 4 doses, and so far no side effects. I am happy to just have started something.