My Mom experiences the same thing. The jitteriness especially. Just on Friday, our home nurse shared something with us which I think explains it. Even before chemo started, Mom felt shaky. She'd been having trouble eating for months before the diagnosis. So she lost about 20 pounds in that time. Since the chemo, the shaking thing or jittery feeling has persisted and become worse. Mom lost more weight over these past months. Mom finally described it like this - it feels like a jackhammer going on in her body. She didn't start outwardly shaking in her hands until the past month. We've asked the Oncologists, nurses at the cancer centre, our family doctor - everyone - about this. Nobody had any answers. We've adjusted meds, removed some for a time, put some new ones in, but nothing resolved the shaking thing.
Finally, the nurse explained it this way. She has a lot of experience with patients with this cancer and just in general. She believes it's a combination of weight loss but also something I call silent pain. The nurse said that sometimes the nerves around the area with cancer become deadened, in the sense that the body is in pain, or the organ with the cancer is in pain, but the nerves are not able to translate that as pain to the patient. So instead, they make the patient shake. Mom has never had pain with her cancer until this week. It turns out, she's probably always had pain, she just couldn't feel it because the nerves were not translating it properly.
I hope this makes sense. The nurse explained it much better than I can. So now, Mom is on pain medicine at a low dose and that helps the shaking. It hasn't stopped entirely but we havent' increased the pain meds yet.We're doing that this week probably.
I don't know if this is the answer for you but it's something I thought helpful to share. This was the one symptom we have not been able to get answers for all these months. It's a relief to know what it is and what to do.
As for the restlessness, Mom takes 0.5 mg or 0.25 mg of Clonazepam and that takes it away.
Hope this helps.