Topic: more info on UK ABC-02 trial) Gemcitabine with or without cisplatin

http://www.asco.org/ASCOv2/Meetings/Abs … ctID=30777

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Re: more info on UK ABC-02 trial) Gemcitabine with or without cisplatin

Can someone explain "Cis (25 mg/m2) followed by Gem (1000 mg/m2 D1, 8 q21d)" for me? It mean use Cisplatin everyday? or only once a week? And what dose " D1, 8 q21d " mean? I don't fully understand. Could some one give me a hand? Thanks in advance.

Re: more info on UK ABC-02 trial) Gemcitabine with or without cisplatin

Hi, Viola,
I don't know what the Cis numbers mean, but the Gem is given on day 1 and day 8 of a 21-day cycle. In my case, Mondays were my usual day for chemo, so I would have the Cis and Gem both on one Monday, the Gemzar alone on the next Monday, and then the next Monday would be no chemo. Each 3 weeks was thus called a cycle, and it took a little over 6 months to do 8 cycles because we delayed the next cycle a couple of times (once because of my work load and once because I was in hospital fighting infections). I believe in both chemicals, the mg/m2 section refers to the quantity of medication and the size of bag for the solution to be in.
I never did see my prescription written out like that, so you must be asking lots of good questions to know that already.
Louise smile

4 (edited by Viola Thu, 10 Sep 2009 19:46:42)

Re: more info on UK ABC-02 trial) Gemcitabine with or without cisplatin

Thank you, Louise.

I tried to searched Dr. Valle JW, the major investigator of this study, on the Pubmed website and I found the Phase II trial has been published on the British Journal of Cancer in August. In that paper, they mentioned in Phase III study, patients' CA19-9 and quality of life was observed. In Phase II trial, they only check the treatment response by image.

Hopefully, they will publish the Phase III trial very soon, I truely want to know in their study, can CA19-9 reflect tumor progression very correctly?

5 (edited by marions Thu, 10 Sep 2009 12:38:58)

Re: more info on UK ABC-02 trial) Gemcitabine with or without cisplatin

Viola

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Re: more info on UK ABC-02 trial) Gemcitabine with or without cisplatin

The members of the North American Task Force for Hepatobiliary Cancer is still in the process of evaluating the data from the above study.  It has been remarked on that metastasis patients did not see a significant benefit over the Gem therapy treatment alone.  But, I am not sure as to whether the data has been evaluated regarding the various metastases and the response rate of each.  I so badly want an answer to this and will try my best to find it.
Marion

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Re: more info on UK ABC-02 trial) Gemcitabine with or without cisplatin

Marion,

Just found these links -

http://www.medpagetoday.com/HematologyO … rapy/19443

http://www.medscape.com/viewarticle/719863

I take it that these news releases today are follow up pieces to the ASCO link that you posted at the start of this thread?

Best wishes,

Gavin

Any advice or comments I give are based on personal experiences and knowledge and are my opinions only, they are not to be substituted for professional medical advice. Please seek professional advice from a qualified doctor or medical professional.

Re: more info on UK ABC-02 trial) Gemcitabine with or without cisplatin

Thanks uncle Gavin.....I agree.  More data is being released.
Thanks for staying on top of this.
Best wishes,
Marion

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Re: more info on UK ABC-02 trial) Gemcitabine with or without cisplatin

This seems to follow suit:
http://www.usnews.com/health/family-hea … ncers.html

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Re: more info on UK ABC-02 trial) Gemcitabine with or without cisplatin

Thanks for that Marion. This is from Cancer Research UK's website today and has a short video from Dr Bridgewater talking briefly about the trial and the results.

http://scienceblog.cancerresearchuk.org … c02-trial/

Best wishes,

Gavin

Any advice or comments I give are based on personal experiences and knowledge and are my opinions only, they are not to be substituted for professional medical advice. Please seek professional advice from a qualified doctor or medical professional.

Re: more info on UK ABC-02 trial) Gemcitabine with or without cisplatin

Thanks, Uncle Gavin.

THIS INFORMATION IS NOT INTENDED NOR IMPLIED TO BE A SUBSTITUTE FOR PROFESSIONAL MEDICAL ADVICE. YOU SHOULD ALWAYS SEEK THE ADVICE OF YOUR PHYSICIAN OR OTHER QUALIFIED HEALTH CARE PROVIDER