Topic: Resveratrol

DISCLAIMER: I don't have any medical training. Please take whatever I write here with a big grain of salt. Always consult your doctor before taking any action.

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I spent some time reading past discussions about supplements. Resveratrol appears to be a popular supplement. I think it's mentioned favorably in the AntiCancer book.

I want to share the result of my research on resveratrol. My conclusion was that my wife should not take it. Here's why.

#1. A quote from Sloat-Kettering page on Resveratrol

http://www.mskcc.org/cancer-care/herb/resveratrol

Several cell culture and animal studies show that resveratrol inhibits proliferation of cancer cells via apoptosis and by exerting anti-estrogenic effects (3) (4) (5) (6). However, contradictory data from other studies showed that it acts as a phytoestrogen and could activate genes that are normally regulated by estrogen (7) or androgen (8).  <snip> Therefore cancer patients with hormone-sensitive diseases, such as estrogen receptor-positive breast cancer and prostate cancer should avoid resveratrol as it may stimulate the proliferation of certain tumor cells.

Further down the same page:

Contraindications

As resveratrol exhibits estrogen-like properties and activates transcription by estrogen receptor and androgen receptor that leads to stimulation of cancer cell proliferation, patients with hormone-sensitive cancers should avoid resveratrol (7)

#2. I asked myself a question: is CC an estrogen-sensitive cancer? I did some googling and came across this study:

Cholangiocarcinoma: An Estrogen-Dependent Cancer?
http://docsdrive.com/pdfs/medwelljourna … /74-79.pdf

I couldn't read the entire study... it's well beyond what I can understand. However, their conclusion seems to be fairly straightforward. They suggest that estrogen plays an important role in sustaining CC cell proliferation.

Putting #1 and #2 together, I decided that the prudent thing to do would be to cross Resveratrol off our list of supplements.

Re: Resveratrol

Eli, this is probably a stupid question, but if cc is estrogen sensitive, is this true for men too? I know we all have both hormones in our body, but would this info be true for men too since they don't have as much estrogen is  their bodies as a woman?

Re: Resveratrol

Tflory, I don't know enough to comment. See my disclaimer in the previous post. No medical education of any kind.

I reached the conclusion that I can't be certain that Resveratrol is safe. That's the gist of my post. "Do not harm".