Topic: 'Natural' does not equal 'Safe'

ScienceDaily summary:

Some Plant-Based Food Supplements Contain High Levels of Cancer Causing Agents, Study Suggests … 123652.htm


Full PDF:

Levels of Genotoxic and Carcinogenic Compounds in Plant Food Supplements and Associated Risk Assessment … perID=8380

Re: 'Natural' does not equal 'Safe'

I don't like the sound of this...

Table 1 on Page 994 (page 6 of the PDF)

Compound: Curcumin
Group: Polyphenol
Carcinogenic: No
Genotoxic: Equivocal


A significant increase of benign neoplastic lesions was observed for rats and mice in a long-term NTP study. However, malignant tumors were not significantly increased compared to the control groups. Moreover, there was a lack of dose-dependent effects as well as consistency across sexes and/or species. Previously, it was concluded by JECFA that curcumin was not genotoxic. However, new in vitro and in vivo studies gave positive results (e.g. DNA adducts and chromosomal aberrations). According to EFSA ‘the available in vivo genotoxicity studies were insufficient to eliminate the concerns regarding genotoxicity’. Nevertheless, there is no carcinogenicity.


Not exactly a ringing endorsement.