Hi - I am new to this Forum but not new to CC. My dad passed away from this dreadful disease 4 1/2 years ago. As crazy as this seems to all of us in my family, my wonderful stepmum has also just been diagnosed with CC. Dad was stage 4 when diagnosed. He did have palliative surgery as his tumor was quite large. Did chemo and a few clinical trials - he fought hard for 1 year and 5 months. My stepmum presented completely different than Dad - she jaundiced, etc. and ended up in the ER and then a couple of hospital stays. They couldn't find anything with the ERCP, MRI, Cat scans, but still pressed on. She has an HMO (which is a nightmare in and of itself) but was fortunate enough to be allowed to go to Cedars Sinai where her amazing gastroenterologist kept at it, because he was certain of the CC diagnosis. She was going to be scheduled for a resection, but her cat scan showed problems with her lungs. Then a pet scan. Then a needle biopsy - and by the grace of God it came back benign. So this Monday we are hoping that they will be again scheduling her for a resection. Her CA19-9 numbers are in the normal range, so we are hoping that this is very early. At this point we do not have a stage. My big questions is: has anyone heard of a husband and wife both being diagnosed with CC? Dad was diagnosed in June of 2006 so there is 6 1/2 year time span between their diagnosis. We have been thinking of everything they might have had in common and there are only two things: massive use of weed killers such as Round Up or Ground Clear with it getting on both of them. Also, they both have undergone major dental work at Loma Linda - such as cutting into the jawbone, bridges, etc. The dental work is most likely far-fetched, but I am wondering seriously about the chemical exposure. While we understand that there might not be any reason, it just is, it's one of those things that runs amuck in the thoughts while trying to process this again. Thank you for any thoughts you can give me - they will be appreciated it. This is truly a monster - still reeling over losing my Dad - I can't even imagine losing my stepmum - she is my best friend.