Topic: anyone ever heard of this treatment?

http://www.iptforcancer.com/

Re: anyone ever heard of this treatment?

Hi Roni,

I haven't heard of it.  So the first thing I did was look it up on Memorial Sloan-Kettering web site.

http://www.mskcc.org/cancer-care/herb/i … on-therapy

Here's the info for consumers:

How It Works

Bottom Line: Insulin Potentiation Therapy is not effective in treating cancer.

Insulin potentiation therapy involves administering insulin at the same time as chemotherapy drugs, with the idea that lower doses of chemo are needed because insulin lets more of the drugs enter cells. However, this has never been proven experimentally. In general, insulin should not been taken by non-diabetics because it can decrease blood sugar to dangerously low levels, causing symptoms such as headache and delirium.

Purported Uses

    * To treat cancer
       There are no data to support this claim.

Research Evidence

No clinical trials have tested the safety or effectiveness of insulin potentiation therapy.

Do Not Take If

    You are taking hypoglycemic agents (IPT can have additive effects).

Side Effects

    Low blood sugar

And here's the summary for healthcare professionals:

Clinical Summary

Insulin Potentiation Therapy (IPT) is an alternative cancer therapy that uses insulin to potentiate the effect of chemotherapy and other medications. This therapy was developed in Mexico by Dr. Donato Perez Garcia in the 1930’s and has been used together with other unconventional therapies for many years (1). Advocates of IPT believe that cancer cells consume more sugar than healthy cells and are therefore more sensitive to insulin and insulin-like growth factor (IGF) (2) (7). Insulin is also believed to increase the permeability of cell membranes, increasing the intracellular concentration and cytotoxic effect of anticancer drugs (1). According to the theory underlying this therapy, if cancer cells can be activated by exogenous insulin, a reduced dose (up to one-tenth the normal dose) of a chemo drug can provide the same cytotoxic effects with less severe adverse reactions. No clinical trials have been performed to validate these claims. In addition, the pharmacokinetic profiles on concurrent use of insulin and chemo drugs are lacking and it is unclear whether the insulin also potentiates the toxic effects of chemotherapy on healthy cells.

Although proponents cite anecdotal case reports suggesting that IPT may be effective, there are no data comparing the efficacy of IPT to conventional chemotherapy. Most of the medications used, such as insulin and other chemo drugs, are approved by the FDA, but the IPT clinics administer them “off-label.” Some clinics that administer IPT are not operated or staffed by oncologists. Side effects of IPT include hypoglycemic reaction. A systematic review of 21 studies showed a correlation between circulating levels of IGF-I, IGFBP3 (IGF-binding protein) and an increased risk of common cancers (8).

Follow the link above to read more details on the MSK web site. You may have to accept their Terms&Conditions before you are able to see the IPT page.

I also searched IPT on the Quackwatch web site. It's a web site that examines "alternative" therapies to see if they have any scientific evidence to back up their claims. Sure enough, they have an article about IPT. Read it and judge yourself.

Why You Should Stay Away from Insulin Potentiation Therapy
http://www.quackwatch.com/01QuackeryRel … r/ipt.html

Re: anyone ever heard of this treatment?

this appears to work, has anyone looked at this:

http://www.medical-center-cologne.com/hyperthermia/

Re: anyone ever heard of this treatment?

Roni,

As to Hyperthermia treatment working, I assume that is what you mean, I can't comment on that. But I think that this is the same treatment that our beloved Kris (Devoncat) tried in 2010. She mentioned this to us here -

http://www.cholangiocarcinoma.org/punbb … hp?id=5377

This link may also be of interest to you as well -

http://www.cancer.gov/cancertopics/fact … perthermia

Best wishes,

Gavin

Any advice or comments I give are based on personal experiences and knowledge and are my opinions only, they are not to be substituted for professional medical advice. Please seek professional advice from a qualified doctor or medical professional.

Re: anyone ever heard of this treatment?

Another link -

http://www.cancer.org/Treatment/Treatme … perthermia

Any advice or comments I give are based on personal experiences and knowledge and are my opinions only, they are not to be substituted for professional medical advice. Please seek professional advice from a qualified doctor or medical professional.

6 (edited by eli Wed, 06 Jun 2012 18:35:25)

Re: anyone ever heard of this treatment?

Hi Roni,

Hyperthermia therapy is interesting (at the very least) because of "Lance Armstrong effect".  See my older post where I explained what "Lance Armstrong effect" is:

http://www.cholangiocarcinoma.org/punbb … 649#p57649

CC patients may*** be eligible for an ongoing clinical trial of hyperthermia given concurrently with regular chemo:

http://clinicaltrials.gov/ct2/show/NCT0 … amp;rank=1

*** I wrote "may be eligible" because I don't know for sure.  I found this trial when I did a search for ongoing trials for extrahepatic CC.  The description of the trial mentions gastric cancer but not CC specifically.

As to the German clinic you linked to, take a look at a recent discussion started by Jose:

http://www.cholangiocarcinoma.org/punbb … hp?id=8091

Re: anyone ever heard of this treatment?

Oh, one more thing:

Before my wife started chemo, we toyed with idea of trying Do-It-Yourself Hyperthermia therapy in combination with chemo. Many commercial spas have dry infrared saunas that are capable of raising body temperature:

http://en.wikipedia.org/wiki/Infrared_sauna

Our idea was to do chemo first, then go straight to a spa and spend another hour in the sauna to raise body temperature. We never tried it though, because our chemo sessions lasted too long (5-6 hours). We were too tired to go anywhere but home. My wife was also afraid of catching germs in a public spa, after her blood counts dropped too low.