Here's the link to the full study:
Cholangiocarcinomas can originate from hepatocytes in mice
Indeed, very interesting. The study challenges the basic assumptions about CC.
The assumption until now was that CC always starts in the bile duct cells (cholangiocytes), while hepatocellular carcinoma (HCC) always starts in the regular liver cells (hepatocytes).
This study found that intrahepatic CC can start in the regular liver cells (hepatocytes). As disease progresses, regular liver cells undergo transformation into cancerous bile duct cells.
The study was done in mice. According to the study, a strong possibility exists that the same transformation can happen in humans. If confirmed, this finding may suggest new targets for drug development.