Topic: Clinical Trial of CPI-613 in Patients with Advanced Bile Duct Cancer

http://130.14.81.50/ct2/show/NCT0176621 … p;lup_d=30

Re: Clinical Trial of CPI-613 in Patients with Advanced Bile Duct Cancer

Hi, interesting, it can cause inflammation,pseudo or not, why? ,I need to do a research on this.
God bless.

Please know that my personal opinion is not intended nor implied to be a substitute for professional medical advice. If  provided, information are for educational purposes.Consult doctor is a MUST for changing of treatment plans.

Re: Clinical Trial of CPI-613 in Patients with Advanced Bile Duct Cancer

Very interesting. Thanks for posting!

A quote from the trial page:

CPI-613 is a novel anti-cancer agent (Zachar et al. 2011). CPI-613 selectively targets the altered form of mitochondrial energy metabolism in tumor cells, causing changes in mitochondrial enzyme activities and redox status which leads to apoptosis, necrosis and autophagy of tumor cells (Zachar et al. 2011). The activities of CPI-613 involve the catalytic and regulatory functions of the altered form of the pyruvate dehydrogenase complex (PDC)

To me this sounds similar to how DCA is supposed to work. The general idea seems to be the same. I'm not an expect, so I can be wrong.

We discussed DCA here:
http://www.cholangiocarcinoma.org/punbb … hp?id=7284

Re: Clinical Trial of CPI-613 in Patients with Advanced Bile Duct Cancer

In response to above - what is a pilot study:

http://www.ncbi.nlm.nih.gov/pubmed/21035130

Hugs,
Marion

THIS INFORMATION IS NOT INTENDED NOR IMPLIED TO BE A SUBSTITUTE FOR PROFESSIONAL MEDICAL ADVICE. YOU SHOULD ALWAYS SEEK THE ADVICE OF YOUR PHYSICIAN OR OTHER QUALIFIED HEALTH CARE PROVIDER