If the chemotherapy works,most of time,if it is required ,it will be continuing the same chemotherapy till "disease progress or intolerable side effects occur. And if it does not work, they will try to switch to other regimen and continue the journey of treatment.
46 years old is by any standard too young not to be treated. New therapies comes out every year;take a chemo vacation now and then if doctor agrees and continue the fighting;be proactive by learning about this disease;find a new way to forget the unfortunate events and reinvent a new strategy to appreciate what is left. I am trying to do exactly what I said above and I am 63. I know it is very tough not to be sad and angry about "why me". But if this is the road I have to travel on, I have no choice but find the best guide book and God's blessing to go ahead. It may not get there, but I know I have try my best for me as well as for my family and friends like your husband.
Please know that my personal opinion is not intended nor implied to be a substitute for professional medical advice. If provided, information are for educational purposes.Consult doctor is a MUST for changing of treatment plans.