Topic: Gemzar & Cisplatin

Hello,

     My Mother, age 53,  just started Gemzar and Cisplatin on 10/04.   Her second treatment was on 10/11 and just consisted of Gemzar.  This was after a six month cycle of 5fu (04/06 to 10/06.)   After receiving the Gemzar and Cisplatin she started to experience intense pain in her abdomen.  The pain would last for about 4 days before subsiding.  I was wondering if anyone else on these drugs had similar symptoms??

Thank You,
  Alison

Re: Gemzar & Cisplatin

My husband, age 50, was on a similar combination of drugs although he had oxiyplatin (sp?) not cisplatin.  He did not experience intense pain but he definitely described abdominal discomfort.  I know the platin drugs have severe side effects.  Maybe someone else on the site will be able to help you.  I know that many others have been on these same drugs.  What does your mom's oncologist say?  Keep us posted.
Best of luck!
Joyce

Re: Gemzar & Cisplatin

alison,

I am sorry that your mother is experiencing pain.  My Dad was on gemcitabine and carboplatin and did not suffer pain, only extreme fatigue the day after chemo, however steriods help with this although he used to feel lousy 'coming down' off the steroids.  Platin drugs are hard on the bone marrow, although have in general been effective for many patients with cc.  Cisplatin is a platin chemo 1st generation and quite harsh, carboplatin is better tolerated (2nd generation) and does the same job, it is newer then cisplatin and oxylplatin is 3rd generation.  Maybe your mum would be better off with a newer platin drug that is not so harsh? - you should discuss this with her oncologist.

Good luck, Jules

Re: Gemzar & Cisplatin

Alison,

I was on Gemzar and cisplatin for 9 treatments.  Very rough with lots of abdominal pains and other side effects.  I have nueropathy in feet and hands because of it.  Oncologist changed from using cisplatin to carboplatin.  A mark difference.  I will say that some tumor shrinkage occured while on cisplatin but only short term effect for me.  Definitely let your Oncologist know.  You should be able to swap to less harsher carboplatin without interupting treatments.

Keep Your Chin Up!   Jeff

Take it to the Limit,One More Time! (Eagles)

Re: Gemzar & Cisplatin

Thank you all for your input!!  It really helps to know people in a similar situation when dealing with this terrible disease.   I will address these issues with our oncologist at our upcoming appointment. 

Thanks Again, Alison

Re: Gemzar & Cisplatin

Hi,
My husband John is on that chemo mix and he complains of a general burning in his abdomen the second day. It is usually gone by the 3rd day.
Hope your Mom gets some relief from the pain. John also experiences extreme fatigue everyday, it doesn't go away until he's ready for his next round. He get's the chemo every 2 weeks.
Good luck to us all,
Charlene

Re: Gemzar & Cisplatin

Just Joined this site, I unfortunately have CCA, (had liver resection) -still got some nasties hanging around. I too have undergone Gemzar & 5FU. Gemzar was quite tollerable but 5FU gave me abdomen pain. My counts (CA19-9) shot up with 5FU. Gemzar seemed to have no effect. Radiation treatment is next.

Steve F

Re: Gemzar & Cisplatin

Hi Steve F.

Welcome.   

I'm sorry to hear that you have CC as well.  When were you diagnosed? The radiation treatment with SIR spheres has been quite helpful to some of us.  Is that the type that you're considering?

G

Re: Gemzar & Cisplatin

Hi,

I just started these two drugs today.  I was diagnosed with CC (left lobe) on 12/15/07.   On Jan. 25, 08, I had surgery at Moffitt Cancer Center in Tampa, FL.  They removed the tumor (9cm x 7cm x 5cm) with clean margins.  A friend of mine in South Carolina had this same cancer and she was told it was not necessary to have chemo.  One year later it metastasized to her lungs.  Because of this I have chosen to do the chemo now.  It has been interesting reading all your comments regarding these two drugs.  I was told to drink water, water, water - till you almost float for the next three days.  I'll let you know how this reacts with me. 

Nancy

"And my God will supply all your needs according to His glorious riches in Christ Jesus." Philippians 4:19

Re: Gemzar & Cisplatin

Welcome Nancy..... Sounds like your off and running and have a plan.  Glad to hear you got clear margins and glad to hear you are going to do some precautionary chemo.  When I had my liver resection and was told clean margins I pressed on without chemo.  I kinda wonder if it would have made a difference as it came back to the other lobe and mets to both my lungs and now in my bones.  I surely hope that doing chemo will get rid of those free radicals in your system before finding a place to nestle.  Stay positive but don't let your guard down for awhile and insist on Ct Scans every 3-4 months of chest, abomen, and pelvic. Yes drink your water and I hope they gave you prescriptions to deal with side effects.  The first sign of nausea, constipation, or loose bowels use the side effect medication as it will definitely make things so much easier.  Eat what you want but maybe smaller portions.  You might want to invest in some stool softener from Walmart and some immodium just in case thing want to flow to much and dehydrate you before you know it.  Wish you the best and please do let us know how thing go.  You sound positive and up beat. That's number one on my list.  Attitude! as hard as it gets sometimes and I get a little down now and then, I keep jumping back to attitude!
God Bless,
Jeff G.

Take it to the Limit,One More Time! (Eagles)

Re: Gemzar & Cisplatin

Jeff, don't wonder too much.  Charlie had chemo and radiation after resection and the cancer came back anyway.  I think everyone reacts so differently - what works for some doesn't work for others.

Nancy, best of luck with your treatment.

Carol

Re: Gemzar & Cisplatin

Hi Carol, your absolutely correct.  I too have had the radiation and enough chemo(AKA) poison to knock this CC out of a horse.  But it still comes back on me as well.  Just maybe when I turn green it will retreat.  I also think it is important to to say the location of primary and how qiuck it was found plays a role.  I'd describe this disease as like a set of christmas lights that aren't all suppose to go out if one bulb burns out but we know that some still do. Then you wiggle the lights and they come on and we replace the bad bulb and hang the lights up and try again.  What an analogy, I don't know if I even understand what I said.  Thanks for not letting me wonder Carol.  I go for check up tomorrow to see how many white blood cells I've got left and hopefully won't need a tranfusion of platelets.  Sorry. I have an attitude today, I just stuck my gut with filgratism for the 67th time. Please forgive me.
God Bless.
Jeff G.

Take it to the Limit,One More Time! (Eagles)

Re: Gemzar & Cisplatin

Hey Jeff,I love the Christmas lights analogy.  Boo for getting stuck with filgratism, but it's a good thing if it helps you.  I detect no attitude except your usual good one Jeff.  You take it and keep on going just what we all need to do. 

Carol

Re: Gemzar & Cisplatin

Hi Jeff, and Carol too,

Well, almost a week has passed since the first round of chemo was given.  I experienced waves of nausea (but no vomiting) and took a pill to help with that.  Constipation has been a problem, but then a pill and lots of fiber in the diet have helped.  Those have thus far been my only symptoms.  I walk on my treadmill every day for 30 minutes, not as fast as I use to, but am getting the excersize needed.  I do appreciate all your comments they are all things I have looked for as I begin this process. 

The best help has been the prayer support I have received from so many people.  I chose to let people know so they could pray with me and I believe God is answering. 

May you be blessed today.
Nancy

"And my God will supply all your needs according to His glorious riches in Christ Jesus." Philippians 4:19

Re: Gemzar & Cisplatin

Hi Nancy, we believe God hears and answers too.  Not always exactly what we want, but He knows and we take comfort in that.  Love to you.

Carol

16 (edited by nancysteck Sun, 11 May 2008 08:12:43)

Re: Gemzar & Cisplatin

Well, round two of my treatment was completed on Friday (May 9).  The aftereffects were about the same as last time.  I felt good the remainder of the day remembering to drink lots of water.  I had a headache as I went to bed, but it did not prevent sleep.  Sat. morning I became nauseous - so took a pill, and that calmed me down.  I was advised by the RN giving the treatment not to let this get out of hand.  The remainder of the day I felt fine even walking on my treadmill for 30 minutes as I do every day, except day of treatment.  This a.m. I'm feeling good. Oh yes, another side effect is definitely hair thinning - or maybe total hair loss to come, but I'll keep you posted on that. 

Yes, Carol, God does answer prayers.  I don't know what I would do do without the prayer support from all my family members and friends. 

Love to all,
Nancy

"And my God will supply all your needs according to His glorious riches in Christ Jesus." Philippians 4:19

17 (edited by JeffG Sun, 11 May 2008 19:05:29)

Re: Gemzar & Cisplatin

Way to go Nancy! keep on trucking! It can be a bit acummulative as you go so keep the nausea meds handy and you'll do fine.  I time when my nausea  usually occured and took before time.  I had hardly any nasuea or vomiting. Some but not that much or as bad as some.
God Bless,
Jeff G.

Take it to the Limit,One More Time! (Eagles)

Re: Gemzar & Cisplatin

Jeff,  I was thinking the same thing that I should take the nausea med on Sat. a.m. as soon as I get up as it is about two hours after I get up that I feel that way.  Maybe that would help solve that nauseated feeling. 
Nancy

"And my God will supply all your needs according to His glorious riches in Christ Jesus." Philippians 4:19

Re: Gemzar & Cisplatin

Well, taking a compazine first thing in the morning solved that nauseous feeling the day after chemo.  Felt good to go the whole day w/o that feeling.  I'm keeping a short diary of how I feel each day during the treatments so I can refer to them and will know what to do after the next treatment.  Well, three down and five to go - almost half way there. 
Nancy

"And my God will supply all your needs according to His glorious riches in Christ Jesus." Philippians 4:19

Re: Gemzar & Cisplatin

Nancy, I'm glad the compazine's working for you.  I wonder if things have changed that much in a year.  When Charlie was diagnosed in 5/07, all the doctors said Gemzar only to start with like it was the absolute first and best thing to do.  It didn't shrink Charlie's tumors at all.  Combination chemos seem to be the way to go now.  Just a thought and a wonder...maybe there's starting to be more data on cc patients and someone's paying attention.  I hope so.  Compazine didn't do a thing for Charlie.  He had to go to Zofran so if one ever stops working for you, don't hesitate to ask for another.  Although, when we got the Zofran, on the packaging from the drug store, it said our insurance saved us $1,164.00 for a bottle of 30 anti-nausea pills.  We paid $5.00.  I just don't understand the price of drugs.  If we didn't have insurance...don't even want to think about it, but I do think of those without any and how frightened and desperate they must feel.  Enjoy the beautiful day!!

Carol

Re: Gemzar & Cisplatin

Nancy... Really glad it did the trick for you.  I do the same thing with stool softener or vegtable laxative tablets.  I just get that feeling and know I should take one or the other.  With pain medications you have a choice; back off on pain meds until the bowel wakes up or take something to temporary wake them to keep things regular.

Bless Ya!
Jeff G.

Take it to the Limit,One More Time! (Eagles)

Re: Gemzar & Cisplatin

Last Friday I reached the 1/2 way of my chemo treatments.  Yesterday I took the compazine first thing again in the morning and felt great, so thanks Jeff for the advice - it sure works.  The Dr. is also now giving me Procrit each Friday and my energy level is again up.  Last week I felt the best I had since before being diagnosed with CC last Nov.  It has been a long journey, but much to be thankful for.  Thanks for all your support.

Nancy

"And my God will supply all your needs according to His glorious riches in Christ Jesus." Philippians 4:19

Re: Gemzar & Cisplatin

Hi Nancy..... Glad to hear all is going well Nancy.  I have not had the need for procit as of yet.  It has been on my mind for this upcoming week though.  I'll have to keep a close watch on those red cells.  I think I'll do just fine though. I'm feeling pretty positive today.
Bless Ya!
Jeff G.

Take it to the Limit,One More Time! (Eagles)

24 (edited by nancysteck Thu, 03 Jul 2008 14:32:31)

Re: Gemzar & Cisplatin

Well, today was my 3/4 mark for infusions - only 2 left and I'm still feeling good with very few side effects from these two drugs.  I also had blood work and CT scan at Moffitt Cancer Center in Tampa this past Monday, June 30.  There are no tumors present in or around the liver at this time.  So I am praising my Lord.  I continue to thank you for your support and help - that is what has helped me get through this process with your suggestions.  Taking that little pill before you get nauseous is certainly the key!

Hope you are having a good day, Jeff.

Thank you,
Nancy

"And my God will supply all your needs according to His glorious riches in Christ Jesus." Philippians 4:19

Re: Gemzar & Cisplatin

Hi Nancy... Glad to hear only 2 cycles left to go.  I'm doing okay thank you.  Just finished cycle 2 of infusion and will now start filgrastim injections tomorrow to counter-act lost of to many white blood cells.  Do lab and nurse eval on Monday to see where platelets and red bloods cells are sitting.  They never quite reached  the normal range last cycle.  I will tell the Doc to hold off for a while this time around as I suspect they'll be a little lower and I need to let them climb back before next cycle.  Your positive attitude is such a plus. 
God Bless,
Jeff G.

Take it to the Limit,One More Time! (Eagles)