Topic: TH-302, or What I learned by reading The Motley Fool

As I've mentioned before, my husband has extrahepatic CCA or possibly pancreatic cancer. Pathologists and his doctors have been unable to make a final diagnosis. We can't see any tumors on his CT scans, only enlarged lymph nodes. Because of this, his doctor frequently looks for treatments and trials for pancreatic cancer. Right now, my husband is receiving gemzar and Abraxane, and it's working pretty well. However, we don't have our next option lined up. His oncologist would like to try a targeted therapy, and in particular would love to get us into a B-Raf trial but hasn't been able to find one that is currently recruiting for either type of cancer.

I hate not having a good plan, so I've been searching, too. Tonight, I stumbled on this fascinating article for investors about pancreatic cancer research and which drugs have the potential to blow the disease out of the water (and make a ton of $).
http://www.fool.com/investing/general/2 … rrent.aspx
I was happy to see Abraxane listed as a top choice, but I had never heard of TH-302. There is a trial near us in New England, so we are going to ask our onc what he thinks about it as a potential next step. Wondering if any of the experts on this board have heard of TH-302 and its potential for helping CCA? Thanks so much!

Re: TH-302, or What I learned by reading The Motley Fool

I don't know anything about it. I just want to post a few links, for the reference.

Wikipedia article on TH-302
http://en.wikipedia.org/wiki/TH-302

TH-302 clinical trials
http://clinicaltrials.gov/ct2/results?term=TH-302

PubMed articles that mention TH-302
http://www.ncbi.nlm.nih.gov/pubmed/?term=TH-302

Searching PubMed for TH-302 and CC doesn't return any results.

Re: TH-302, or What I learned by reading The Motley Fool

SweetGreen....sorry, this is the first I have heard of it too. 
Hugs
Marion

THIS INFORMATION IS NOT INTENDED NOR IMPLIED TO BE A SUBSTITUTE FOR PROFESSIONAL MEDICAL ADVICE. YOU SHOULD ALWAYS SEEK THE ADVICE OF YOUR PHYSICIAN OR OTHER QUALIFIED HEALTH CARE PROVIDER

Re: TH-302, or What I learned by reading The Motley Fool

Never heard of it either SweetGreen but found this -

http://www.thresholdpharm.com/sec/tumor_hypoxia

http://www.cancer.gov/drugdictionary?cdrid=560194

http://www.ascopost.com/issues/february … inoma.aspx

http://www.cancer.gov/clinicaltrials/se … ofessional

http://www.thresholdpharm.com/pdf/borad … o_9-09.pdf

Hope some of these are useful to you.

Gavin

Any advice or comments I give are based on personal experiences and knowledge and are my opinions only, they are not to be substituted for professional medical advice. Please seek professional advice from a qualified doctor or medical professional.

Re: TH-302, or What I learned by reading The Motley Fool

Hi,

This links to an abstract about TH302 in treating pancreatic Cancer.

http://abstracts2.asco.org/AbstView_132_114561.html

TPS4148

God bless

Please know that my personal opinion is not intended nor implied to be a substitute for professional medical advice. If  provided, information are for educational purposes.Consult doctor is a MUST for changing of treatment plans.