Topic: Transarterial chemoembolization - any thoughts?

Hi all,

I'm currently in the process of researching treatments for stage IV ICC and came across transarterial chemoembolization. I was wondering whether anyone has any personal experience of this treatment. Any thoughts would be greatfully received.

Thanks,
Jules

Re: Transarterial chemoembolization - any thoughts?

Sorry, just realised that I've posted this in the wrong section smile

Re: Transarterial chemoembolization - any thoughts?

Hi,
An easy( relatively speaking) procedure( TACE) or chemoembo is a palliative treatment to give a large dose of chemotherapy like cisplatin,mitomycin and adriamycin to the tumor in the liver thru arteries to the tumor sites. It is not a long term solution for the disease but can extend the quality of life and time hopefully long enough for other new treatment or medications to come around.

God bless.

Please know that my personal opinion is not intended nor implied to be a substitute for professional medical advice. If  provided, information are for educational purposes.Consult doctor is a MUST for changing of treatment plans.

Re: Transarterial chemoembolization - any thoughts?

Hi Jules,

I can't comment from experience, but I am also looking into this therapy area (my wife has unresectable ICC).

One promising chemoembolization therapy I found was Drug-Eluting Beads with IRInotecan (DEB-IRI). 

Here is a presentation that discusses the procedure:

http://www.biocompatibles.com/uploads/d … /APP20.pdf

A research paper describing some of the results is here:

http://www.stencor.com.br/ingles/arquiv … eraphy.pdf

The paper reports on results from this procedure on 24 patients.  The paper describes the number of partial responses and median survival.  The part of the results that caught my eye were:

"Three patients were downstaged to resection and
underwent subsequent hepatectomy with radiofrequency
ablation. Three patients showed a complete response with
100% loss of positron emission tomography scan activity.
Of these, 1 patient remains free of disease (follow-up time,
33.8 months) and 2 patients are alive with disease (followup
time, 33.3 and 80 months)."

***Although I can't figure out why the abstract claims only 1 patient was downgraded to resection...

Here is a clinical trial evaluating the procedure:

http://clinicaltrials.gov/ct2/show/NCT01648023

please understand that I am not a doctor and I am just doing my own research the same as you.  As such, I can't really say whether this is a good idea or not for you.  However, I did want to make sure you knew it was out there.

Jason

Re: Transarterial chemoembolization - any thoughts?

Hi Jason,

Thank you very much for your reply and the links. This looks promising to me and I'll let you know if I find anything further. It brings some comfort to know that there are others in the same situation and we can share knowledge in beating CC. Do let me know how your wife gets on with her treatment.

Best wishes to you and your wife,

Jules

Re: Transarterial chemoembolization - any thoughts?

Hmm.  Not sure what happened to the link to the presentation, but here it is again.

http://www.biocompatibles.com/uploads/d … /APP20.pdf

Jason

Re: Transarterial chemoembolization - any thoughts?

interesting...they (the drs) are talking about trying something like
this next on my husband (who is not a candidate for surgery...well,
ever because of mets to lymph nodes and lungs.)

thanks for sharing this....wrong section and all! smile

Re: Transarterial chemoembolization - any thoughts?

My husband's doctor has talked about this possibility also.  Thank you Percy and Jason for posting such helpful information about it.