Topic: The New Cancer Drugs In Development and On FDA"Fast Tract Approval"

Hi, everyone,
yesterday i post some basic understanding of what is gene amplification and overexpression. the reason is simple, If you take a look the new research drug development by Pharma(see below) ,all if not the most for cancer researched drugs are base on the gene sequence and positions,like CD20,PD-1,PDL-1,ALK,CDK4 and BDK and P13k etc.
Last but not least below is the link to cancer new  drug development now and the next year that most of them,if clinical trials successful, will be approval by FDA on a "FAST TRACT" basis.
Even the new potential cancer drugs are not developed specially for our kind of tumor--cholangiocarcinmoa; most likely they will be soon or dispensed as "off the label use" .
I will pay more attention   about those  drugs in development that  are related to the immune system of our body, and if it works out for us, we will be free at last, at least as  to be treated as a  chronic disease   rather than a deadly one and has no return.


http://www.fiercebiotech.com/special-re … ?page=full

God bless.

Please know that my personal opinion is not intended nor implied to be a substitute for professional medical advice. If  provided, information are for educational purposes.Consult doctor is a MUST for changing of treatment plans.

Re: The New Cancer Drugs In Development and On FDA"Fast Tract Approval"

Percy this is astounding news as it could mean, like you say, down the road new drugs for CC. We pray that it is sooner than later. Thank so much.

Teddy ~In our hearts forever~ATTITUDE is EVERYTHING
Any suggestion I offer is intended as friendly advice based solely on my own experience. Please consult your doctor for professional guidance.

Re: The New Cancer Drugs In Development and On FDA"Fast Tract Approval"

Thanks Percy for all your research. Hopefully these really are fast track drugs and their benefits will become reality soon.

Carl

Re: The New Cancer Drugs In Development and On FDA"Fast Tract Approval"

Thanks Percy.
How are you feeling? We pray for you daily.
Hugs
Lisa

This Information Is Not Intended Nor Implied To Be A Substitute For Professional Medical Advice. You Should Always Seek The Advice Of Your Physician Or Other Qualified Health Care Provider

Re: The New Cancer Drugs In Development and On FDA"Fast Tract Approval"

Hi, Lisa,

I feel fine and thanks for your prayer daily.

As far as the situation goes, I will not know the exact responses from the RFA and PEI procedures  and the daily  oral Tarceva until my next PET scan in September.

Thanks again for your prayer daily for me and I will do the same for everyone.

God bless.

Please know that my personal opinion is not intended nor implied to be a substitute for professional medical advice. If  provided, information are for educational purposes.Consult doctor is a MUST for changing of treatment plans.

Re: The New Cancer Drugs In Development and On FDA"Fast Tract Approval"

Hi Percy,

You seem to be very knowledgeable regarding the various treatments for CC.  my doctor has me on Paclitaxel right now and I'm wondering if you know anything about this drug?  She has told me that she has seen some success using it for CC.  I haven't seen it mentioned on any posts here and wonder if it will be helpful for me?

Just some background info on me...I was diagnosed with adenocarcinoma unknown primary in August 2011.  Primary popped up in February 2013 in my liver and that's when I was diagnosed with CC stage IV because there is lymph node involvement and also tumor wrapped around celiac trunk.  I've already had chemo regimen of 5-FU, Oxaliplatin, Leucovorin.  Then had 28 treatments of traditional radiation. After that had Gemcitabine.  Chemo didn't seem to do much.  Traditional radiation killed the tumor wrapped around the celiac trunk but that started showing activity again in February of this year.  In May of this year I had 5 SBRT treatments which seems to have stabilized the tumors - no growth so that's good.  And now I'm on the Paclitaxel.

Any input/advice would be much appreciated.

Thanks,
Mary

7 (edited by PCL1029 Wed, 07 Aug 2013 13:24:42)

Re: The New Cancer Drugs In Development and On FDA"Fast Tract Approval"

Hi, Mary,

In general, "Paclitaxel-(Taxol) a chemo agent in the Taxane family that  primary inhibits the cell cycle during mitosis;thus the tumor cell cannot duplicated and  die;Taxol should be given before cisplatin if both drugs are used at the same time for maximum benefit of the combo.;also inhibits angiogenesis but is  tough to take.
Additional info: 0/15 response rate ,(JCO August 1996 vol.14 no8 2306-2310. Newer agent like  Nab-paclitaxel  studies will come later."

With regard to your case, the first thing that come to my mind is you had 28 radiation treatments plus 5 SBRT in May,and  therefore "radiation recall reaction"which  may occur to patients who have received previous radiation will be a concern that you may have to address to your oncologist. Symptoms included nonproductive cough,dyspnea, and oxygen desatuaration.  Radiation pneumonitis,pneumonia has been also reported.

Apart from that, watch closely about  the  liver enzymes AST,ALT,alkaline phosphates and total bilirubin level ; dose reduction may be required if bilirubin>1.5 and AST/ALT.>2 times the upper limit of normal.
The loss of the body hair is the most common side effects(87-100%); hematologic side effects included  neutropenia(90%),
leukopenia(90%),thrombocytopenia(20%)and anemia(78%). Most of these side effects are  more significantly influenced by the duration of infusion (3hr course or 24hour ) versus  the dose given.
Fever (12%) was reported and therefore chances for  febrile neutropenia
(2-55%) and opportunistic infections(30%) cannot be ignored.
Other side effects included  myalgia and arthralgia(60%),hypotension, mucositis,peripheral neuropathy, nausea/vomiting(52%),diarrhea(38%),
visual disturbances ,tiredness and ascites are not uncommon.
You may or may not have any of the above side effects; These are just for information purposes only.
God bless.

Please know that my personal opinion is not intended nor implied to be a substitute for professional medical advice. If  provided, information are for educational purposes.Consult doctor is a MUST for changing of treatment plans.

Re: The New Cancer Drugs In Development and On FDA"Fast Tract Approval"

Percy,

Thanks so much for all the info.  I never heard of radiation recall reaction so I looked it up and will discuss with my doctor on Friday.  I'm concerned with abdominal pain I've been having lately and wonder if it has anything to do with the radiation I've had and now this chemo.  All my level enzymes are high and they're watching them closely along with my white, red and platelet counts.  They decided to go ahead with the chemo because they got my bilirubin down from 22.1 to 1.2 - thanks to the stent they put in my liver in May.  So far I haven't had any breathing problems and my oxygen level has been good as of my last appt on 7/19. 

As for the Paclitaxel...I get it over a hour once a week for two weeks then off a week then back on.  I have already lost my hair and have seen a lost in my energy level.  Also had some flu-like symptoms but not severe.  They are watching my counts closely and will stop treatment if they go too low.