Topic: Can combination metronomic therapy overcome chemoresistance in cholang

Can combination metronomic therapy overcome chemoresistance in cholangiocarcinoma? A literature review.

http://www.ncbi.nlm.nih.gov/pubmed/23979207

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Re: Can combination metronomic therapy overcome chemoresistance in cholang

Just seen this. It looks really interesting. Is anyone giving this a go?

Re: Can combination metronomic therapy overcome chemoresistance in cholang

Hi Jules,

I haven't heard of anyone here going through this but if someone has I hope that they will post their experiences of it here. I did a quick search of the site and couldn't find anything else on it either.

Best wishes,

Gavin

Any advice or comments I give are based on personal experiences and knowledge and are my opinions only, they are not to be substituted for professional medical advice. Please seek professional advice from a qualified doctor or medical professional.

Re: Can combination metronomic therapy overcome chemoresistance in cholang

Thanks Gavin. I'm going to ask my parents to take the article along to the oncologist in a few weeks time, and see what she says. The abstract sounds promising but I don't have access to the full article as yet.

Re: Can combination metronomic therapy overcome chemoresistance in cholang

Ignore that, i've just accessed the article. Still looks good smile

Re: Can combination metronomic therapy overcome chemoresistance in cholang

Jules....Continuous low-dose  metronomic/anti-angiogenic chemotherapy (chemo administered over time) has been used by others in a palliative setting.  In fact, Percy used Xeloda, for several months. It will be interesting to see the response of the physician as to whether he/she will prefer a rapid approach to cell devision or, address it from another angle (anti-angiogenic mechanism) of cell devision.
All my best wishes are heading your way,
Hugs,
Marion

THIS INFORMATION IS NOT INTENDED NOR IMPLIED TO BE A SUBSTITUTE FOR PROFESSIONAL MEDICAL ADVICE. YOU SHOULD ALWAYS SEEK THE ADVICE OF YOUR PHYSICIAN OR OTHER QUALIFIED HEALTH CARE PROVIDER

Re: Can combination metronomic therapy overcome chemoresistance in cholang

Thanks for that Marion. And Jules, glad you got access to the full article and please let us know what the onc says about it all etc. Hope things go well for your mum.

Best wishes,

Gavin

Any advice or comments I give are based on personal experiences and knowledge and are my opinions only, they are not to be substituted for professional medical advice. Please seek professional advice from a qualified doctor or medical professional.

Re: Can combination metronomic therapy overcome chemoresistance in cholang

thank you as always, Gavin, for your postings. This is a fascinating article! For me, who cannot do any more traditional chemos, this looks promising. I will look into it with my dcs.

Re: Can combination metronomic therapy overcome chemoresistance in cholang

You're most welcome Holly. I hope that it will be of use to you and please let us know what your docs says about it etc.

Hugs,

Gavin

Any advice or comments I give are based on personal experiences and knowledge and are my opinions only, they are not to be substituted for professional medical advice. Please seek professional advice from a qualified doctor or medical professional.