Topic: Has immunotherapy ever caused shrinkage?

Just a query re immunotherapy. I was wondering if anyone has ever tried an immunotherapy that has managed to cause any shrinkage to a tumour, as opposed to keeping it stable, or would something like this be asking a little too much at this point in time? I feel that something like this may be possible one day... fingers crossed.

My mum is just about to start gem/cis and is a little apprehensive to say the least. So we’re trying to keep a few steps ahead, and to think of alternative options for the future, so that she is with us and well, for a long time to come.

Re: Has immunotherapy ever caused shrinkage?

I don't know the answer to this... I think as far as cc is concerned, it may b too early.
I am on a trial for an inhibitor, and it is working to keep me stable. But it was not really "built" to shrink cancer cells, just keep it stable, and prohibit new growth.
I'm hoping, like you, that soon there will be a breakthrough. For now, I will take "stable"!!!

KrisJ
"Don't just have minutes in the day; have moments in time."
Any opinions I give are based on personal experiences, and are not based on medical knowledge. I strongly suggest receiving medical care and opinions.

Re: Has immunotherapy ever caused shrinkage?

Jules,
Your mum may do better than she thinks on gem/cis and if not, there are other types and combos of chemo that have had success in shrinking tumors.  I'm not aware of any immunotherapy for CC either, though I am very intrigued by it in general.

Yes, Kris, stable is a wonderful thing!

Willow

4 (edited by PCL1029 Mon, 09 Sep 2013 19:45:16)

Re: Has immunotherapy ever caused shrinkage?

Hi,

Most of "the immunology  in cancer" research links put on this message board about anti-PD1 PDL-1 antibodies , vaccines and  adoptive cell (ie: TIL) confirm not only CR or PR(complete or partial response )but  PFS is longer and less side effects.
One of the purposes of published medical journal articles is to provide case  studies (experience in a control setting);by reading them ,even just the summary, will give the reader about the experiences that the research had for that particular research. I am  just a patient ,but I do believe by providing and reading the articles helps me a lot in understanding about this disease and provide me a better chance to survive longer and a better quality of life if God willing.
Have you have time to read  some of the articles on the message board ?
If not , the answer is YES., read link below to understand more if interested.

http://www.miamiherald.com/2013/07/26/3 … ising.html

God bless.

Please know that my personal opinion is not intended nor implied to be a substitute for professional medical advice. If  provided, information are for educational purposes.Consult doctor is a MUST for changing of treatment plans.

Re: Has immunotherapy ever caused shrinkage?

Hello all, thank you for your replies.

Kris - 'stable' is a wonderful wonderful word. How fantastic - we'd take 'stable' any day! My mum has just had a repeat scan this month (her last scan was in June), and the tumour had not grown at all. She'd had no treatment in the intermin (long story), so the tumour must be very slow growing or else her immune system must be fighting very hard.

Yes, i've started to read a lot of the research and am on the case with immunotherapy. I really do think that there will be something available to beat all cancers, one day in the future. In the meantime, my mum is trialling a vaccine containing mycrobacterium vaccae, alongside her chemo. She's just started this. It's not a clinical trial per se, but is a general 'immuno-vaccine' that has been trialled with some promising results in other cancers. It's never been trialled in CC so we really are taking a leap of faith. Some say that we are mad to be giving this a go but our Oncologist has agreed, and since she's given my mum such a dismal prognosis then we have decided that it's worth a shot. I'll keep you all updated on her progress.

Best wishes to all,
Jules

Re: Has immunotherapy ever caused shrinkage?

Jules if it was not for 'pioneers' like your Mum taking a first step to try something new, where would we be today? I give her and you a lot of credit and its great that your ONC agrees! We will be anxious to see how this goes and of course hoping it goes great!

Teddy ~In our hearts forever~ATTITUDE is EVERYTHING
Any suggestion I offer is intended as friendly advice based solely on my own experience. Please consult your doctor for professional guidance.

Re: Has immunotherapy ever caused shrinkage?

Jules,
I second what Lainy wrote! Yay for you and your mum to try something new in hopes it will work! Imagine being able to say you were in the trials of this breakthrough cure!! That's why I joined the trial... Not for personal kudos but to hopefully help myself and others if the trial is successful, which it seems it is.
Thanks for the link, Percy... I knew you could be counted on for some good information.

KrisJ
"Don't just have minutes in the day; have moments in time."
Any opinions I give are based on personal experiences, and are not based on medical knowledge. I strongly suggest receiving medical care and opinions.

Re: Has immunotherapy ever caused shrinkage?

Jules...I agree with the others.  Although; cancer is not homogeneous, it does have structual similarities hence, their is a crossover to other diseases.  And, for that reason the vaccine given to your Mom may very well promote a positive response.  Drug studies are focused on a particular disease or, as is the case with cancer, one one or sometimes more similar cancers.  The physician has the ability to use a particular drug "off label."
I wish for continued success and am sending tons of good wishes your way.
Hugs,
Marion

THIS INFORMATION IS NOT INTENDED NOR IMPLIED TO BE A SUBSTITUTE FOR PROFESSIONAL MEDICAL ADVICE. YOU SHOULD ALWAYS SEEK THE ADVICE OF YOUR PHYSICIAN OR OTHER QUALIFIED HEALTH CARE PROVIDER

9 (edited by Regina Mon, 30 Sep 2013 22:16:02)

Re: Has immunotherapy ever caused shrinkage?

From all I've researched, along wit my family, it appears that immunotherapy will be the way (or one of the ways) of the future fight on cancer.  There were very many tempting trials and immunological treatments -- I've delved into the work of immunotherapy centers in all parts of the world -- but I chose to go the way of a MEK trial for now.  I'd be very interested to hear how this goes.  Much luck to you and your mom!!
Regina