Topic: MEK/Pazopanib

I am thinking of entering a MEK/Pazopanib trial.  I'm wondering if anyone has done anything similar.  I have a flagrant recurrence of ICC with many mets in my liver.

This is a wonderful group of people!  I love all the support you all offer.  I am still trying to figure out how to navigate this site.

All the best to you,
Regina

Re: MEK/Pazopanib

Trial update:

After a false attempt at J Hopkins due to an inadvertently departing clinical team member, I was accepted for the same trial at MDAnderson.  I think they may be transferring me back up to Hopkins on my request, since I live in NYC.

I have been on the trial for 18 days now.  Side effects, as expected, have been sleepiness, an acne rash (not too attractive), and diarrhea.  Caffeine, topical Clindamycin and Immodium have been my friends.  I may have to start the oral antibiotic for the acne, as it probably won't let up as long as I'm on these meds.

Meanwhile, my blood work looks really good, including most liver enzymes (ALT, Alk Phos)(AST went up a bit), except platelets, which have surprisingly gone down to 68 (this is not quite expected).  AND, CA19-9 has gone down to 83 from 109!!  I'm not sure how that's possible in two weeks, so I'm not putting too much stock in its significance.

This seems to be a very promising regimen, according to results seen in the (small number) of cholangio patients treated.

If anyone wants to discuss, please contact me.

Cheers,
Regina

Re: MEK/Pazopanib

Regina, how promising! And I figure my acne rash is worth it...I use the topical cream, but can't put it in my scalp!
Please keep us all informed on how the trial goes, as many of us are interested in any of these trials. Your next scan should be great with the promising blood work.
Good luck with transferring back up to NY.

KrisJ
"Don't just have minutes in the day; have moments in time."
Any opinions I give are based on personal experiences, and are not based on medical knowledge. I strongly suggest receiving medical care and opinions.