We certainly do forge ahead on this path as intrepid travelers. After a couple of chemo protocols to treat a recurrence three years post resection, and having weighed many options and consulted with five docs, I have enrolled in the MEK/Pazopanib trial (that Holly mentioned). I first went to Hopkins to see Dr. Azad, but they lost an important staff person to an unforeseen leave and have not been able to enroll anyone so far. She referred me to Drs. Shroff and Zinner at MDAnderson in Houston and we made the schlep there a week ago. The medical center is impressive; the city oppressive.
Despite some initial trepidations about timing, they were able to get all the testing done within those five days and start me on the trial as of Tuesday 9/23. So far, so good. Some fatigue is hitting, along with hypersensitive skin on my face.
Both meds have been FDA approved individually for other cancers, but not in combination. The Phase I part of the trial included all solid tumors and has been going on for two years with good success. It was due to the surprisingly good response of two cholangio patients that the researchers won a grant to add 25 cholangio patients to the trial. I think it is not officially Phase II, but the dose has been established and side effects logged for two years.
I'd love to know if anyone else on here is enrolled. I'd be glad to chat with anyone considering it.