Topic: si-DNMT1 restore tumor suppressor genes expression through the reversa

si-DNMT1 restore tumor suppressor genes expression through the reversal of DNA hypermethylation in cholangiocarcinoma.

"Targeted knockdown of human DNA methyltransferase 1 expression restores the expression levels of tumor suppressor genes, thus inhibiting the proliferation of QBC939 cells. These results may provide insight for the development of novel therapies for cholangiocarcinoma."

http://www.ncbi.nlm.nih.gov/pubmed/24361215

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