Topic: What does no mutations in genetic testing mean?

Hi everyone,

My mom's genetic testing from MGH came back (I had to ask for the results; they're not announced automatically) as showing no mutations.

Could someone please explain what means?  I also asked my mom's NP, but I thought I'd ask here too.  I'll post the response from the NP when I get it.

Many thanks in advance,
Caroline

Re: What does no mutations in genetic testing mean?

I'm answering my own question here.

These are the questions I asked my mom's medical team:

What does it mean that my mom's genetic testing came back with no mutations?  Does that tell us anything about what treatments are more effective than others for her?  How does that figure into the trial on Cabozantinib?  Does the test result affect the possible efficacy of the drug on my mom?

Here's their response:

These results have no impact on her current trial, either candidacy or efficacy. It simply means her tumor has no specific mutations. This is neither good not bad. And it really doesn't direct or guide future treatments other than to say she would not be a candidate for a trial using a drug that targets a mutation she doesn't have. We can discuss more at her next appointment. But bottom line it has no immediate implications on her treatment.

Re: What does no mutations in genetic testing mean?

My mom has the BRAF mutation.  Apparently this mutation is common in melanoma.  Before starting the cabozatinib trial Dr. Zhu tried to get her in a trial of another medicine targeting this mutation, I think it was called Vemurafenib, but it was closed and unless she could pay out of pocket for the medicine ($13,000 per month) it wasn't an option.

Re: What does no mutations in genetic testing mean?

I'm having my previous biopsies sent out for genomic testing, too. I am interested in which mutations respond better to which treatments. I figure it might not do me any good, but the more knowledge out there, the better for everyone. It might take a few years to have enough genetic information on cc patients, but I'm doing what I can NOW!

KrisJ
"Don't just have minutes in the day; have moments in time."
Any opinions I give are based on personal experiences, and are not based on medical knowledge. I strongly suggest receiving medical care and opinions.

Re: What does no mutations in genetic testing mean?

Kris, 

Can't hurt to try and it may be of some help.   Like you said, you are doing what you can NOW!   Let us know what results you get.

Darla

"One Day At A Time"

All of my comments and suggestions are just my opinions and are not a substitute for professional medical advice.   You should always seek the advice of your physician or other qualified health care providers.

Re: What does no mutations in genetic testing mean?

Darla, don't worry. I think we are going to need a sticky for thus, too... For everyone who has had genetic testing to post in one area.
Maybe even have everyone state treatments and responses, also... Hhmmm.... Something to ponder. Marion, Percy, Lainy, Gavin, etc., etc., etc.,... What do you think? How should we do this? It has the potential of getting quite large as genomic testing becomes more common.
Percy  I think it was you that had a topic about this? And urging everyone to find out if possible.

KrisJ
"Don't just have minutes in the day; have moments in time."
Any opinions I give are based on personal experiences, and are not based on medical knowledge. I strongly suggest receiving medical care and opinions.