Topic: Researchers personalize drug treatments using genomic sequencing

Maybe this is old news, but I came across it just today and thought I'd share.

http://www.news-medical.net/news/201402 … ncing.aspx

Physicians at Mayo Clinic's Individualized Medicine Clinic and researchers at the Translational Genomics Research Institute (TGen) have personalized drug treatments for patients with cholangiocarcinoma using genomic sequencing technologies. Potential new treatment approaches are being validated to develop new tests that physicians can use to guide therapy for this aggressive cancer of the bile ducts that progresses quickly and is difficult to treat.

Clinically important findings suggest that targeting the epidermal growth factor receptor (EGFR) and the fibroblast growth factor receptor (FGFR) cellular pathways may benefit thousands of patients with this disease, according to the study published today in the journal PLOS Genetics.

Half of the patients treated in this study responded to either ponatinib (typically used for certain types of leukemia) or pazopinib (a kidney cancer drug), depending on the genetic alterations identified through sequencing.

"In 3 out of the 6 patients we analyzed, we found compelling, treatable and unexpected genetic alterations that would never have been found by normal testing methods for cholangiocarcinoma," says Mitesh Borad, M.D., a Mayo Clinic oncologist and lead author of the paper. "We treated these three patients with drugs that attack these genetic alterations and saw tumor shrinkage. This gives us hope for better treatments for this aggressive, hard-to-treat cancer."

Because of these encouraging early results, the team of 49 doctors and researchers proposes large-scale clinical trials to test EFGR and FGFR inhibitors as possible treatments for biliary tract cancers that harbor mutations in these genes and pathways.

"Our results demonstrate that if we find the right molecular context, more appropriate therapies can be chosen that improve outcomes," says John Carpten, Ph.D., TGen deputy director of basic science and director of TGen's Integrated Cancer Genomics Division, and the study's senior author. "We now hope to design larger clinical studies to treat patients' tumors harboring these novel genomic aberrations to further explore the precise extent of clinical benefit for patients with primary or advanced cholangiocarcinoma."

Bile duct cancer is a rare cancer that occurs mostly in people older than age 50. Surgical approaches, such as resection and liver transplantation, represent the only curative treatment approaches, says Dr. Borad. Most patients, however, present with surgically unresectable or metastatic disease at the time of diagnosis. Standard-of-care chemotherapies are not curative and there is an unmet need for newer approaches, Dr. Borad adds.

Source: Mayo Clinic

Re: Researchers personalize drug treatments using genomic sequencing

Mark, thank you.  I have copied your post and am taking it with me to Mayo on April 8th to discuss having the molecular testing done to see if there is a genetic problem that caused my ICC.

"Just for today, I can get through anything."  Hey....I'm a cancer survivor, not a doctor.  The opinions I state are my own, based on my personal experiences or knowledge.  As always, talk to your doctor about your concerns and treatment.

Re: Researchers personalize drug treatments using genomic sequencing

Hi, everyone,
I went thru the chemotesting by Target NOW report, and the next Generation gene seauencing profile. I also saw the doctor at Mayo's Individualized Medicine Clinic .
My conclusion:    Target NOW  will list the drugs that patient will be more sensitive to and Foundation ONE report will report the gene mutations of the patient; but neither is of great benefits to patients who are suffering now.
In short, most oncologists do not pay attention to the reports now due to the fact that this are new technology  but few proven new drug to work with.

BTW, I feel a bit better, stop loss of weight, Megace helps to increase appetite, and I eat more now as compare a month ago. I use ibuprofen and cut the Oxycontin dose in half  for my back pain and use Miralax to help constipation. I sleep much better than a month ago (now I sleep almost 8hr/nite) with the pain pills and sleeping aid.Hot bath 2-3 times daily helps the pain; doctor visit every week  and he plans a PET scan in 3 month instead of 2month . I am sure I will ask for earlier PET to be done. Fatigue is a major problem since now the oncologist put me back on Xeloda 1gm twice a week every  5days out of 7 days to slow the growth of the tumor.
If I have more energy, I will look into TIL@NIH.

Thanks for those  who pray for me and I hope other patients will improve their conditions as well.
This is really not an easy journey to take.

God bless.

Please know that my personal opinion is not intended nor implied to be a substitute for professional medical advice. If  provided, information are for educational purposes.Consult doctor is a MUST for changing of treatment plans.

Re: Researchers personalize drug treatments using genomic sequencing

I'm seeing many references to back pain smatterd about the discussions.

What's the cause of it generally?

I'm having some post op after a resection and attribute it just to poor posture for the past 10 weeks along with a loss of muscle strength. I'm expecting mine to go away but would like to know if there's something I'm missing...?

I'm glad to hear you're sleep and appetite have improved and will pray for you!

PCL1029 wrote:

Hi, everyone,
I went thru the chemotesting by Target NOW report, and the next Generation gene seauencing profile. I also saw the doctor at Mayo's Individualized Medicine Clinic .
My conclusion:    Target NOW  will list the drugs that patient will be more sensitive to and Foundation ONE report will report the gene mutations of the patient; but neither is of great benefits to patients who are suffering now.
In short, most oncologists do not pay attention to the reports now due to the fact that this are new technology  but few proven new drug to work with.

BTW, I feel a bit better, stop loss of weight, Megace helps to increase appetite, and I eat more now as compare a month ago. I use ibuprofen and cut the Oxycontin dose in half  for my back pain and use Miralax to help constipation. I sleep much better than a month ago (now I sleep almost 8hr/nite) with the pain pills and sleeping aid.Hot bath 2-3 times daily helps the pain; doctor visit every week  and he plans a PET scan in 3 month instead of 2month . I am sure I will ask for earlier PET to be done. Fatigue is a major problem since now the oncologist put me back on Xeloda 1gm twice a week every  5days out of 7 days to slow the growth of the tumor.
If I have more energy, I will look into TIL@NIH.

Thanks for those  who pray for me and I hope other patients will improve their conditions as well.
This is really not an easy journey to take.

God bless.

Re: Researchers personalize drug treatments using genomic sequencing

Percy,

Glad to hear that you are getting more sleep and able to eat more.   Any and all improvements are a good thing.  Sounds like you are keeping pain under control, too.

Wishing you well and continued improvement.

Thoughts and prayers going out to you.

Love & Hugs,
Darla

"One Day At A Time"

All of my comments and suggestions are just my opinions and are not a substitute for professional medical advice.   You should always seek the advice of your physician or other qualified health care providers.

Re: Researchers personalize drug treatments using genomic sequencing

Just seen your update Percy, many thanks for that. Am real glad to hear you say that you are sleeping and eating a bit better then before, very very glad in fact. Hope that you manage to keep the pain under control and I know that getting the 8 hours a night will be so beneficial to you.

Happy also to hear that the magace is doing it's job and that you have an appetite again. I know from my dad's experiences that he felt a load better if I could get a good meal in him, a good steak he used to like!

You take care now Percy and please know that I think of you lots. And go Bears as well!

Gavin

Any advice or comments I give are based on personal experiences and knowledge and are my opinions only, they are not to be substituted for professional medical advice. Please seek professional advice from a qualified doctor or medical professional.