My husband was diagnosed with extrahepatic cc and had a successful resection in March 2014--He did not have clear margins, and there is lymph node involvemend--he was diagnosed as stage 4. He went through 5 weeks of radiation/chemo therapy and is now on chemo alone. Last week he developed the shakes--the doctor called it rigger. When it started, he didn't have a fever, but shortly after we got to the emergency room his temperature went to 102. It stayed at 102 for about an hour, and went back to normal. He had xrays, cat scans, blood tests--there was nothing new that should have caused this. He stayed overnight in the hospital, and was released. He went a week, and now has had another episode. I contacted his oncology team, and we decided to monitor at home to see what happened. His temp spiked to 102.2, stayed there for about an hour, and then returned to normal. Has anyone else experienced this type of reaction. From everything I have seen, this usually is an indication of infection--but his scans and blood test do not show anything. Any thoughts and advice will be appreciated.