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This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors that have a KRAS G12C mutation.

ClinicalTrials.gov Identifier
NCT03785249
Institution Name
Multiple Sites (See Below)
Full Institution Address





United States
Additional Institutions

United State, Alabama

  • University of Alabama at Birmingham Recruiting

  • Birmingham, Alabama, United States, 35294


United States, Alaska

  • Alaska Oncology and Hematology Recruiting

  • Anchorage, Alaska, United States, 99508

  • United States, Arizona

  • Mayo Clinic in Arizona Recruiting

  • Phoenix, Arizona, United States, 85054

  • Arizona Oncology Associates Recruiting

  • Tucson, Arizona, United States, 85704


United States, California

  • Kaiser Permanente-Bellflower Medical Offices Recruiting

  • Bellflower, California, United States, 90706

  • Beverly Hills Cancer Center Recruiting

  • Beverly Hills, California, United States, 90211

  • City of Hope Recruiting

  • Duarte, California, United States, 91010

  • St. Joseph Heritage Healthcare Recruiting

  • Fullerton, California, United States, 92835

  • University of California San Diego Moores Cancer Center Recruiting

  • La Jolla, California, United States, 92093

  • Hoag Memorial Hospital Presbyterian Recruiting

  • Newport Beach, California, United States, 92663

  • University of California, Irvine Recruiting

  • Orange, California, United States, 92868

  • California Cancer Associates for Research and Excellence Recruiting

  • San Diego, California, United States, 92111

  • Ridley - Tree Cancer Center - Santa Barbara Recruiting

  • Santa Barbara, California, United States, 93105

  • Kaiser Permanente Recruiting

  • Vallejo, California, United States, 94589


United States, Colorado

  • Rocky Mountain Cancer Centers Recruiting

  • Aurora, Colorado, United States, 80012

  • University of Colorado Hospital Recruiting

  • Aurora, Colorado, United States, 80045

  • St. Mary's Hospital & Regional Medical Center - Research Recruiting

  • Grand Junction, Colorado, United States, 81501


United States, Connecticut

  • Yale Cancer Center Recruiting

  • New Haven, Connecticut, United States, 06511


United States, Delaware

  • Medical Oncology Hematology Consultants Recruiting

  • Newark, Delaware, United States, 19713


United States, Florida

  • Mayo Clinic in Florida Recruiting

  • Jacksonville, Florida, United States, 32224

  • Mount Sinai Comprehensive Cancer Center Recruiting

  • Miami Beach, Florida, United States, 33140

  • Miami Cancer Institute Baptist Health Recruiting

  • Miami, Florida, United States, 33176

  • Mid Florida Hematology and Oncology Center Recruiting

  • Orange City, Florida, United States, 37263

  • Woodlands Medical Specialists Recruiting

  • Pensacola, Florida, United States, 32503

  • BRCR Medical Center Recruiting

  • Plantation, Florida, United States, 33322


United States, Georgia

  • Northwest Georgia Oncology Centers, PC Recruiting

  • Marietta, Georgia, United States, 30060


United States, Illinois

  • Illinois Cancer Specialists - Niles Recruiting

  • Niles, Illinois, United States, 60714


United States, Iowa

  • University of Iowa Hospital & Clinics Recruiting

  • Iowa City, Iowa, United States, 52242


United States, Kansas

  • University of Kansas Medical Center Recruiting

  • Westwood, Kansas, United States, 66205


United States, Kentucky

  • University of Kentucky Recruiting

  • Lexington, Kentucky, United States, 40536


United States, Maine

  • Main Health Cancer Center Biddeford Recruiting

  • Biddeford, Maine, United States, 04005


United States, Maryland

  • Maryland Oncology Hematology-Columbia Recruiting

  • Columbia, Maryland, United States, 21044


United States, Massachusetts

  • Massachusetts General Hospital Recruiting

  • Boston, Massachusetts, United States, 02114

  • Dana Farber Cancer Institute Recruiting

  • Boston, Massachusetts, United States, 02215


United States, Michigan

  • Henry Ford Medical Center Recruiting

  • Detroit, Michigan, United States, 48377


United States, Minnesota

  • Minnesota Oncology Recruiting

  • Minneapolis, Minnesota, United States, 55102

  • University of Minnesota Recruiting

  • Minneapolis, Minnesota, United States, 55454

  • Mayo Clinic in Minnesota Recruiting

  • Rochester, Minnesota, United States, 55905

  • Metro-Minnesota Community Oncology Research Consortium Recruiting

  • Saint Louis Park, Minnesota, United States, 55416


United States, Missouri

  • Goldschmidt Cancer Center- Central Region Medical Center Recruiting

  • Jefferson City, Missouri, United States, 65109


United States, Montana

  • Frontier Cancer Center Recruiting

  • Billings, Montana, United States, 59102


United States, Nebraska

  • Nebraska Cancer Specialists Recruiting

  • Omaha, Nebraska, United States, 68130

  • University of Nebraska Medical Center Recruiting

  • Omaha, Nebraska, United States, 68198


United States, Nevada

  • Comprehensive Cancer Centers of Nevada Recruiting

  • Las Vegas, Nevada, United States, 89169


United States, New York

  • Roswell Park Recruiting

  • Buffalo, New York, United States, 14263

  • Perlmutter Cancer Center Recruiting

  • New York, New York, United States, 10016

  • Memorial Sloan Kettering Cancer Center Recruiting

  • New York, New York, United States, 10065


United States, North Carolina

  • University of North Carolina Recruiting

  • Chapel Hill, North Carolina, United States, 27514

  • FirstHealth Outpatient Cancer Center Recruiting

  • Pinehurst, North Carolina, United States, 28374


United States, Ohio

  • University of Cincinnati Health Barrett Cancer Center Recruiting

  • Cincinnati, Ohio, United States, 45219

  • Cleveland Clinic Recruiting

  • Cleveland, Ohio, United States, 44195

  • OSU Medical Center Recruiting

  • Columbus, Ohio, United States, 43210

  • Kettering Cancer Center Recruiting

  • Kettering, Ohio, United States, 45429


United States, Oregon

  • Willamette Valley Cancer Institute and Research Center - Eugene Recruiting

  • Eugene, Oregon, United States, 97401


United States, Pennsylvania

  • Lehigh Valley Heath Recruiting

  • Allentown, Pennsylvania, United States, 18103

  • Penn State Health Milton S. Hershey Medical Center Recruiting

  • Hershey, Pennsylvania, United States, 17033


United States, South Carolina

  • Charleston Oncology P.A. Recruiting

  • Charleston, South Carolina, United States, 29414

  • Medical University of South Carolina Recruiting

  • Charleston, South Carolina, United States, 29425


United States, Tennessee

  • Tennessee Oncology/The Sarah Cannon Research Institute Recruiting

  • Nashville, Tennessee, United States, 37203


United States, Texas

  • Texas Oncology-Arlington Recruiting

  • Arlington, Texas, United States, 76014

  • USOR - Texas Oncology - Austin Central Recruiting

  • Austin, Texas, United States, 78731

  • Mary Crowley Cancer Research Recruiting

  • Dallas, Texas, United States, 75231

  • Texas Oncology at Presbyterian Dallas Recruiting

  • Dallas, Texas, United States, 75231

  • USOR Texas Oncology Baylor Charles A. Sammons Cancer Center Recruiting

  • Dallas, Texas, United States, 75246

  • Texas Oncology Recruiting

  • Fort Worth, Texas, United States, 76104

  • The University of Texas MD Anderson Cancer Center Recruiting

  • Houston, Texas, United States, 77030

  • South Texas Accelerated Research Therapeutics Recruiting

  • San Antonio, Texas, United States, 78229

  • Texas Oncology Recruiting

  • Sugar Land, Texas, United States, 77479

  • Texas Oncology Recruiting

  • Tyler, Texas, United States, 75702


United States, Virginia

  • Virginia Cancer Specialists Recruiting

  • Fairfax, Virginia, United States, 22031

  • Virginia Oncology Associates-Newport News Recruiting

  • Newport News, Virginia, United States, 23606


United States, Washington

  • Seattle Cancer Care Alliance Recruiting

  • Seattle, Washington, United States, 98109

  • USOR - Compass Oncology - Vancouver Recruiting

  • Vancouver, Washington, United States, 98684


United States, Wisconsin

  • University of Wisconsin Carbone Cancer Center Recruiting

  • Madison, Wisconsin, United States, 53792


Puerto Rico

  • PanOncology Trials Recruiting

  • San Juan, Puerto Rico, 00935
Principal Investigator
Multiple Sites
Principal Investigator Phone
(844) 893-5530
Principal Investigator Email
miratistudylocator@emergingmed.com
Additional Principal Investigators
Please visit https://clinicaltrials.gov/ct2/show/NCT03785249 for the latest information
Study Coordinator
Mirati Therapeutics Study Locator Services
Study Coordinator Phone
(844) 893-5530
Study Coordinator Email
miratistudylocator@emergingmed.com
Study Overview
This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors that have a KRAS G12C mutation.
Enrollment Information
565 participants
Study Start Date
20190930
Study End Date
20240930
Study Purpose

  • This study will evaluate the safety, tolerability, pharmacokinetics, metabolites, pharmacodynamics, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors with a KRAS G12C mutation. MRTX849 (adagrasib) is an orally-available small molecule inhibitor of KRAS G12C.
Inclusion Criteria

  • Histologically confirmed diagnosis of a solid tumor malignancy with KRAS G12C mutation

  • Unresectable or metastatic disease

  • Standard treatment is not available or patient declines

  • Adequate organ function
Exclusion Criteria

  • History of intestinal disease or major gastric surgery or inability to swallow oral medications

  • Other active cancer
Required Tests Prior to Study
KRASG12C mutation, which will be identified by the healthcare team
Financial Assistance Available
Yes