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Clinical Trials

Targeted Therapy
Expanded Access of Adagrasib (MRTX849) in Patients With Advanced Solid Tumors Who Have a KRAS G12C Mutation
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Beyond First Line Therapy
This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors that have a KRAS G12C mutation.
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Beyond First Line Therapy
Basket Study of Tucatinib and Trastuzumab in Solid Tumors With HER2 Alterations
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Beyond First Line Therapy
ICP-CL-00303
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Beyond First Line Therapy
Phase II Study of combination of Trametinib (MEK inhibitor) and Hydroxychloroquine (HCQ) (autophagy inhibitor) in Patients with KRAS Mutation Refractory Bile Tract Carcinoma (BTC)
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Immunotherapy
Ivosidenib (AG-120) With Nivolumab in IDH1 Mutant Tumors
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Beyond First Line Therapy
A Single Arm Phase II Study of the Combination of DKN-01 and Nivolumab in Previously Treated Patients with Advanced Biliary Tract Cancer (BTC)
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First Line Therapy
PROOF Trial: Phase 3 Study of BGJ398 (Oral Infigratinib) in First Line Cholangiocarcinoma With FGFR2 Gene Fusions/Translocations
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Beyond First Line Therapy
Study of A166 in Patients With Relapsed/Refractory Cancers Expressing HER2 Antigen or Having Amplified HER2 Gene
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Targeted Therapy
Study of LOXO-101 in Subjects With NTRK Fusion Positive Solid Tumors Phase II, multi-center, open-label study of patients with advanced solid tumors harboring a fusion of NTRK1, NTRK2 or NTRK3
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Beyond First Line Therapy
Safety and Tolerability of TNG462 in Patients with MTAP-deleted Solid Tumors
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