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Clinical Trials

Beyond First Line Therapy
A Study to Evaluate KIN-3248 (study drug) in Patients with Advanced Tumors Who Have FGFR2 and//or FGFR3 Gene Alterations
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Targeted Therapy
A Phase 2, Multi-Center Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients with Advanced Solid Tumors Harboring PTCH1 Loss of Function Mutations
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Chemotherapy
ZW25-201: A Phase 2 Study of Zanidatamab (ZW25; bispecific antibody) Plus First-line Chemotherapy in HER2-Expressing Cancers, Including Cholangiocarcinoma (Bile Duct Cancer), Gallbladder Cancer, and Colorectal Cancer
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Beyond First Line Therapy
Safety and Tolerability of TNG908 in Patients with MTAP-deleted Solid Tumors
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Targeted Therapy
Expanded Access of Adagrasib (MRTX849) in Patients With Advanced Solid Tumors Who Have a KRAS G12C Mutation
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Beyond First Line Therapy
This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors that have a KRAS G12C mutation.
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Beyond First Line Therapy
Basket Study of Tucatinib and Trastuzumab in Solid Tumors With HER2 Alterations
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Beyond First Line Therapy
ICP-CL-00303
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Beyond First Line Therapy
Phase II Study of combination of Trametinib (MEK inhibitor) and Hydroxychloroquine (HCQ) (autophagy inhibitor) in Patients with KRAS Mutation Refractory Bile Tract Carcinoma (BTC)
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Immunotherapy
Ivosidenib (AG-120) With Nivolumab in IDH1 Mutant Tumors
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Beyond First Line Therapy
CAR-macrophages for the Treatment of HER2 Overexpressing Solid Tumors
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Other Novel Therapies
Modified Immune Cells (Autologous Dendritic Cells) and a Vaccine (Prevnar) After High-Dose External Beam Radiation Therapy in Treating Patients With Unresectable Liver Cancer
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